Pancreatic cancer in HIV-positive patients: A clinical case-control study

Ernesto Zanet; Massimiliano Berretta; Fabrizio Di Benedetto; Renato Talamini; Roberto Ballarin; Giuseppe Nunnari; Salvatore Berretta; Annalisa Ridolfo; Arben Lleshi; Antonio Zanghì; Alessandro Cappellani; Umberto Tirelli

doi:10.1097/MPA.0b013e31824a0e40

Pancreatic cancer in HIV-positive patients: A clinical case-control study

Ernesto Zanet, Massimiliano Berretta, Fabrizio Di Benedetto, Renato Talamini, Roberto Ballarin, Giuseppe Nunnari, Salvatore Berretta, Annalisa Ridolfo, Arben Lleshi, Antonio Zanghì, Alessandro Cappellani, Umberto Tirelli

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: Pancreatic cancer (PC) is the fourth and fifth most common cause of cancer-related death among men in United States and in Europe, respectively. No data are available for HIV-positive patients. The aim of this study was to investigate and to compare clinical presentation and outcome between HIV-positive and HIV-negative PC patients. METHODS: From April 1988 to June 2010, the Italian Cooperative Group on AIDS and Tumors identified 16 cases of HIV-positive PC patients. Each HIV-positive patient from our institution was randomly matched (ratio 1:2) with HIV-negative patients (32 controls) based on sex and year of PC diagnosis. Differences in clinical presentation, treatment, and overall survival were assessed. RESULTS: At multivariate analysis, HIV-positive patients compared with HIV-negative patients had a higher risk of an unfavorable performance status (PS ≥2) and a younger age (

Original language	English
Pages (from-to)	1331-1335
Number of pages	5
Journal	Pancreas
Volume	41
Issue number	8
DOIs	https://doi.org/10.1097/MPA.0b013e31824a0e40
Publication status	Published - Nov 2012

Keywords

HAART
HIV
pancreatic cancer
performance status
survival

ASJC Scopus subject areas

Hepatology
Internal Medicine
Endocrinology
Endocrinology, Diabetes and Metabolism

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Pancreatic cancer in HIV-positive patients : A clinical case-control study. / Zanet, Ernesto ; Berretta, Massimiliano; Benedetto, Fabrizio Di; Talamini, Renato; Ballarin, Roberto; Nunnari, Giuseppe; Berretta, Salvatore; Ridolfo, Annalisa; Lleshi, Arben; Zanghì, Antonio; Cappellani, Alessandro; Tirelli, Umberto.

In: Pancreas, Vol. 41, No. 8, 11.2012, p. 1331-1335.

Research output: Contribution to journal › Article › peer-review

Zanet, Ernesto ; Berretta, Massimiliano ; Benedetto, Fabrizio Di ; Talamini, Renato ; Ballarin, Roberto ; Nunnari, Giuseppe ; Berretta, Salvatore ; Ridolfo, Annalisa ; Lleshi, Arben ; Zanghì, Antonio ; Cappellani, Alessandro ; Tirelli, Umberto. / Pancreatic cancer in HIV-positive patients : A clinical case-control study. In: Pancreas. 2012 ; Vol. 41, No. 8. pp. 1331-1335.

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