TY - JOUR
T1 - Pancreatic cancer in HIV-positive patients
T2 - A clinical case-control study
AU - Zanet, Ernesto
AU - Berretta, Massimiliano
AU - Benedetto, Fabrizio Di
AU - Talamini, Renato
AU - Ballarin, Roberto
AU - Nunnari, Giuseppe
AU - Berretta, Salvatore
AU - Ridolfo, Annalisa
AU - Lleshi, Arben
AU - Zanghì, Antonio
AU - Cappellani, Alessandro
AU - Tirelli, Umberto
PY - 2012/11
Y1 - 2012/11
N2 - OBJECTIVES: Pancreatic cancer (PC) is the fourth and fifth most common cause of cancer-related death among men in United States and in Europe, respectively. No data are available for HIV-positive patients. The aim of this study was to investigate and to compare clinical presentation and outcome between HIV-positive and HIV-negative PC patients. METHODS: From April 1988 to June 2010, the Italian Cooperative Group on AIDS and Tumors identified 16 cases of HIV-positive PC patients. Each HIV-positive patient from our institution was randomly matched (ratio 1:2) with HIV-negative patients (32 controls) based on sex and year of PC diagnosis. Differences in clinical presentation, treatment, and overall survival were assessed. RESULTS: At multivariate analysis, HIV-positive patients compared with HIV-negative patients had a higher risk of an unfavorable performance status (PS ≥2) and a younger age (
AB - OBJECTIVES: Pancreatic cancer (PC) is the fourth and fifth most common cause of cancer-related death among men in United States and in Europe, respectively. No data are available for HIV-positive patients. The aim of this study was to investigate and to compare clinical presentation and outcome between HIV-positive and HIV-negative PC patients. METHODS: From April 1988 to June 2010, the Italian Cooperative Group on AIDS and Tumors identified 16 cases of HIV-positive PC patients. Each HIV-positive patient from our institution was randomly matched (ratio 1:2) with HIV-negative patients (32 controls) based on sex and year of PC diagnosis. Differences in clinical presentation, treatment, and overall survival were assessed. RESULTS: At multivariate analysis, HIV-positive patients compared with HIV-negative patients had a higher risk of an unfavorable performance status (PS ≥2) and a younger age (
KW - HAART
KW - HIV
KW - pancreatic cancer
KW - performance status
KW - survival
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U2 - 10.1097/MPA.0b013e31824a0e40
DO - 10.1097/MPA.0b013e31824a0e40
M3 - Article
C2 - 22695133
AN - SCOPUS:84868302810
VL - 41
SP - 1331
EP - 1335
JO - Pancreas
JF - Pancreas
SN - 0885-3177
IS - 8
ER -