Pancreatic cancer in HIV-positive patients: A clinical case-control study

Ernesto Zanet, Massimiliano Berretta, Fabrizio Di Benedetto, Renato Talamini, Roberto Ballarin, Giuseppe Nunnari, Salvatore Berretta, Annalisa Ridolfo, Arben Lleshi, Antonio Zanghì, Alessandro Cappellani, Umberto Tirelli

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: Pancreatic cancer (PC) is the fourth and fifth most common cause of cancer-related death among men in United States and in Europe, respectively. No data are available for HIV-positive patients. The aim of this study was to investigate and to compare clinical presentation and outcome between HIV-positive and HIV-negative PC patients. METHODS: From April 1988 to June 2010, the Italian Cooperative Group on AIDS and Tumors identified 16 cases of HIV-positive PC patients. Each HIV-positive patient from our institution was randomly matched (ratio 1:2) with HIV-negative patients (32 controls) based on sex and year of PC diagnosis. Differences in clinical presentation, treatment, and overall survival were assessed. RESULTS: At multivariate analysis, HIV-positive patients compared with HIV-negative patients had a higher risk of an unfavorable performance status (PS ≥2) and a younger age (

Original languageEnglish
Pages (from-to)1331-1335
Number of pages5
JournalPancreas
Volume41
Issue number8
DOIs
Publication statusPublished - Nov 2012

Keywords

  • HAART
  • HIV
  • pancreatic cancer
  • performance status
  • survival

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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