Pancreatic involvement during the early phase of shock

Raffaele Pezzilli, Antonio Maria Morselli-Labate, Elisabetta Romboli, Francesco Dibenedetti, Margherita Massa, Marina Migliori, Bahjat Barakat, Giampaolo Merlini, Roberto Corinaldesi, Gian Vico Melzi d'Eril

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: There is a lack of data concerning pancreatic involvement during shock. Aim: To evaluate possible pancreatic alterations in the early phase of shock. Setting: Twelve consecutive patients with shock were studied within 2 hours from the onset of illness. Seven patients died during the hospital stay: 3 within 4 hours from admission, 3 within 4-8 hours and 1 within 12 hours. Main outcome measures: Amylase, lipase, C-reactive protein, amyloid A, interleukin 6 procalcitonin and vascular cell adhesion molecule-1 serum concentrations were determined on admission and 4, 8, and 12 hours afterward. All patients underwent imaging studies of the pancreas. Results: None of the patients developed clinical signs or morphological alterations compatible with acute pancreatitis. Serum amylase levels were above the upper reference limit in 7 patients (58.3%) and serum lipase levels in 2 patients (16.7%; P=0.062). There were no significant differences found between survivors and non-survivors in the serum concentrations of all the proteins studied. Conclusions: In patients with shock, amylase seems to be more frequently elevated than lipase. None of the patients showed pancreatic alterations at imaging techniques.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalJournal of the Pancreas
Volume3
Issue number5
Publication statusPublished - Sep 2002

Fingerprint

Shock
Amylases
Lipase
Serum
Vascular Cell Adhesion Molecule-1
Calcitonin
Amyloid
Pancreatitis
C-Reactive Protein
Survivors
Pancreas
Interleukin-6
Length of Stay
Outcome Assessment (Health Care)
Proteins

Keywords

  • Acute-phase proteins
  • Amylases
  • Clinical medicine
  • Lipase
  • Pancreatitis
  • Shock

ASJC Scopus subject areas

  • Endocrinology
  • Gastroenterology

Cite this

Pezzilli, R., Morselli-Labate, A. M., Romboli, E., Dibenedetti, F., Massa, M., Migliori, M., ... Melzi d'Eril, G. V. (2002). Pancreatic involvement during the early phase of shock. Journal of the Pancreas, 3(5), 139-143.

Pancreatic involvement during the early phase of shock. / Pezzilli, Raffaele; Morselli-Labate, Antonio Maria; Romboli, Elisabetta; Dibenedetti, Francesco; Massa, Margherita; Migliori, Marina; Barakat, Bahjat; Merlini, Giampaolo; Corinaldesi, Roberto; Melzi d'Eril, Gian Vico.

In: Journal of the Pancreas, Vol. 3, No. 5, 09.2002, p. 139-143.

Research output: Contribution to journalArticle

Pezzilli, R, Morselli-Labate, AM, Romboli, E, Dibenedetti, F, Massa, M, Migliori, M, Barakat, B, Merlini, G, Corinaldesi, R & Melzi d'Eril, GV 2002, 'Pancreatic involvement during the early phase of shock', Journal of the Pancreas, vol. 3, no. 5, pp. 139-143.
Pezzilli R, Morselli-Labate AM, Romboli E, Dibenedetti F, Massa M, Migliori M et al. Pancreatic involvement during the early phase of shock. Journal of the Pancreas. 2002 Sep;3(5):139-143.
Pezzilli, Raffaele ; Morselli-Labate, Antonio Maria ; Romboli, Elisabetta ; Dibenedetti, Francesco ; Massa, Margherita ; Migliori, Marina ; Barakat, Bahjat ; Merlini, Giampaolo ; Corinaldesi, Roberto ; Melzi d'Eril, Gian Vico. / Pancreatic involvement during the early phase of shock. In: Journal of the Pancreas. 2002 ; Vol. 3, No. 5. pp. 139-143.
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