Abstract
Islet cell transplantation recently has emerged as one the most promising therapeutic approaches to improving glycometabolic control in type 1 diabetic patients, and, in many cases, to obtaining insulin independence. Islet cell transplantation requires a relatively short hospital stay and has the advantage of being a relatively noninvasive procedure. The rate of insulin independence 1 year after islet cell transplantation has improved significantly in recent years (60% at 1 year after transplantation compared to the 15% in the past years). Data from a recent international trial confirmed that islet cell transplantation potentially can be a cure for type 1 diabetes. Recent data indicate that insulin independence after islet cell transplantation is associated with an improvement in glucose metabolism and quality of life and with a reduction in hypoglycemic episodes. Islet cell transplantation is still in its initial stages, and many obstacles still need to be overcome. Once clinical islet transplantation has been established, this treatment could be offered to diabetic patients long before the onset of diabetic complications or to patients with life-threatening hypoglycemic unawareness and brittle diabetes.
| Original language | English |
|---|---|
| Pages (from-to) | 999-1013 |
| Number of pages | 15 |
| Journal | Endocrinology and Metabolism Clinics of North America |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Dec 2007 |
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ASJC Scopus subject areas
- Endocrinology
- Biochemistry
Cite this
Pancreatic Islet Cell Transplant for Treatment of Diabetes. / Fiorina, Paolo; Secchi, Antonio.
In: Endocrinology and Metabolism Clinics of North America, Vol. 36, No. 4, 12.2007, p. 999-1013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pancreatic Islet Cell Transplant for Treatment of Diabetes
AU - Fiorina, Paolo
AU - Secchi, Antonio
PY - 2007/12
Y1 - 2007/12
N2 - Islet cell transplantation recently has emerged as one the most promising therapeutic approaches to improving glycometabolic control in type 1 diabetic patients, and, in many cases, to obtaining insulin independence. Islet cell transplantation requires a relatively short hospital stay and has the advantage of being a relatively noninvasive procedure. The rate of insulin independence 1 year after islet cell transplantation has improved significantly in recent years (60% at 1 year after transplantation compared to the 15% in the past years). Data from a recent international trial confirmed that islet cell transplantation potentially can be a cure for type 1 diabetes. Recent data indicate that insulin independence after islet cell transplantation is associated with an improvement in glucose metabolism and quality of life and with a reduction in hypoglycemic episodes. Islet cell transplantation is still in its initial stages, and many obstacles still need to be overcome. Once clinical islet transplantation has been established, this treatment could be offered to diabetic patients long before the onset of diabetic complications or to patients with life-threatening hypoglycemic unawareness and brittle diabetes.
AB - Islet cell transplantation recently has emerged as one the most promising therapeutic approaches to improving glycometabolic control in type 1 diabetic patients, and, in many cases, to obtaining insulin independence. Islet cell transplantation requires a relatively short hospital stay and has the advantage of being a relatively noninvasive procedure. The rate of insulin independence 1 year after islet cell transplantation has improved significantly in recent years (60% at 1 year after transplantation compared to the 15% in the past years). Data from a recent international trial confirmed that islet cell transplantation potentially can be a cure for type 1 diabetes. Recent data indicate that insulin independence after islet cell transplantation is associated with an improvement in glucose metabolism and quality of life and with a reduction in hypoglycemic episodes. Islet cell transplantation is still in its initial stages, and many obstacles still need to be overcome. Once clinical islet transplantation has been established, this treatment could be offered to diabetic patients long before the onset of diabetic complications or to patients with life-threatening hypoglycemic unawareness and brittle diabetes.
UR - http://www.scopus.com/inward/record.url?scp=35648982927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35648982927&partnerID=8YFLogxK
U2 - 10.1016/j.ecl.2007.07.004
DO - 10.1016/j.ecl.2007.07.004
M3 - Article
C2 - 17983933
AN - SCOPUS:35648982927
VL - 36
SP - 999
EP - 1013
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
SN - 0889-8529
IS - 4
ER -