TY - JOUR
T1 - Pancreatic metastasis from mycosis fungoides mimicking primary pancreatic tumor
AU - Ceriolo, P.
AU - Fausti, V.
AU - Cinotti, Elisa
AU - Bonadio, Silvia
AU - Raffaghello, Lizzia
AU - Bianchi, Giovanna
AU - Fraternali Orcioni, Giulio
AU - Fiocca, Roberto
AU - Rongioletti, Franco
AU - Pistoia, Vito
AU - Borgonovo, Giacomo
PY - 2016/3/28
Y1 - 2016/3/28
N2 - Mycosis fungoides (MF) is a cutaneous T-cell lymphoma that can undergo local progression with possible systemic dissemination. We report a case of a patient affected by MF with a pancreatic mass that was a diagnostic challenge between primitive tumor and pancreatic metastasis from MF. Clinical setting findings and imaging studies raised the suspicion of a pancreatic primary neoplasm. A diagnostic clue was provided by the combined histomorphologic/immunohistochemical study of pancreatic and cutaneous biopsies, which revealed a pancreatic localization of MF. Considering the rarity of metastatic localization of MF to the pancreas, we next investigated whether chemokinechemokine receptor interactions could be involved in the phenomenon to provide new insight into the possible mechanisms underlying metastatic localization of MF to the pancreas. Histological analyses of archival pancreatic tissue demonstrated that glucagon-secreting cells of the pancreatic islets expressed the CCL27 chemokine, which may have attracted in our case metastatic MF cells expressing the complementary receptor CCR10.
AB - Mycosis fungoides (MF) is a cutaneous T-cell lymphoma that can undergo local progression with possible systemic dissemination. We report a case of a patient affected by MF with a pancreatic mass that was a diagnostic challenge between primitive tumor and pancreatic metastasis from MF. Clinical setting findings and imaging studies raised the suspicion of a pancreatic primary neoplasm. A diagnostic clue was provided by the combined histomorphologic/immunohistochemical study of pancreatic and cutaneous biopsies, which revealed a pancreatic localization of MF. Considering the rarity of metastatic localization of MF to the pancreas, we next investigated whether chemokinechemokine receptor interactions could be involved in the phenomenon to provide new insight into the possible mechanisms underlying metastatic localization of MF to the pancreas. Histological analyses of archival pancreatic tissue demonstrated that glucagon-secreting cells of the pancreatic islets expressed the CCL27 chemokine, which may have attracted in our case metastatic MF cells expressing the complementary receptor CCR10.
KW - CCL27 CCR10
KW - Differential diagnosis
KW - Extracutaneous localization
KW - Mycosis fungoides
KW - Pancreatic mass
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U2 - 10.3748/wjg.v22.i12.3496
DO - 10.3748/wjg.v22.i12.3496
M3 - Article
VL - 22
SP - 3496
EP - 3501
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 12
ER -