Pancreatic metastasis from renal cell carcinoma: Which patients benefit from surgical resection?

Alessandro Zerbi, Enrico Ortolano, Gianpaolo Balzano, Anna Borri, Aldo Alberto Beneduce, Valerio Di Carlo

Research output: Contribution to journalArticlepeer-review


Background: Pancreas is a possible site of metastases from renal cell carcinoma (RCC). The aim of this study was to define the role of surgery in their treatment. Methods: We retrospectively analyzed 36 patients with pancreatic metastasis from RCC observed between January 1998 and February 2006. Patients were categorized into three risk groups according to the modified Memorial Sloan-Kettering prognostic factors model. Results: Resective surgery was performed in 23 patients, as follows: 11 distal pancreatectomy, 5 enucleation, 4 pancreatoduodenectomy, 2 total pancreatectomy, and 1 middle pancreatectomy. No perioperative mortality was observed; the morbidity rate was 47.8%. All patients who underwent resection belonged to the favorable risk group. Surgical resection was excluded in 13 cases because of locally advanced disease (2 cases) or extrapancreatic disease (11 cases); 5 of these patients were at favorable, 7 at intermediate, and 1 at poor risk. In patients undergoing surgery, the 5-year actuarial survival rate was 88%, and median disease-free survival was 44 months. Patients who did not undergo surgery had a 5-year survival rate of 47%, with a median survival time of 27 months (P = .02). Conclusions: Patients with pancreatic metastases from RCC belonging to a favorable risk group are candidates for resection, even in the presence of another metastatic site or multifocal pancreatic disease.

Original languageEnglish
Pages (from-to)1161-1168
Number of pages8
JournalAnnals of Surgical Oncology
Issue number4
Publication statusPublished - Apr 2008


  • Pancreas
  • Pancreatic metastases
  • Pancreatic resection
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Surgery
  • Oncology


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