Pancreatic multicenter ultrasound study (PAMUS)

Mirko D'Onofrio, Emilio Barbi, Christoph F. Dietrich, Masayuki Kitano, Kazushi Numata, Atsushi Sofuni, Francesco Principe, Anna Gallotti, Giulia A. Zamboni, Roberto Pozzi Mucelli

Research output: Contribution to journalArticle

Abstract

Aim: To describe the typical CEUS pattern of pancreatic lesions and to evaluate the diagnostic accuracy of Contrast-enhanced ultrasound (CEUS) in their characterization. Materials and methods: All US and CEUS examinations of focal pancreatic masses performed in six centers during a period of five years were reviewed. Inclusion criteria were: focal pancreatic mass pathologically proved, visible at ultrasound (US) and studied with CEUS. All lesions were then evaluated for size, aspect and enhancement pattern. Sensitivity, specificity, positive and negative predictive values with 95% CIs were calculated to define diagnostic accuracy of CEUS in respect to pathology. Diagnostic confidence of US and CEUS, discerning between benign and malignant lesions, were represented by using ROC (receiver operating characteristics) curves. Agreement was evaluated by means of k statistics. Results: 1439 pancreatic lesions were included. At CEUS the lesions were divided into solid (89%) and cystic (12%) masses and classified into six and eight categories, respectively. Among the solid lesions, adenocarcinomas were characterized with an accuracy of 87.8%. Among the cystic lesions, cystic tumors were diagnosed with an accuracy of 97.1%. ROC curve area increased from 0.637 for US to 0.877 for CEUS (p <0.0001). Inter-observer agreement was slightly higher for solid (k = 0.78) than cystic (k = 0.62) lesions. In none of the centers side effects were reported. Conclusion: CEUS is accurate in the characterization of pancreatic lesions. CEUS should be considered as a complementary imaging method for pancreatic lesions characterization.

Original languageEnglish
Pages (from-to)630-638
Number of pages9
JournalEuropean Journal of Radiology
Volume81
Issue number4
DOIs
Publication statusPublished - Apr 2012

Fingerprint

ROC Curve
Multicenter Studies
Ultrasonography
Adenocarcinoma
Pathology
Sensitivity and Specificity
Neoplasms

Keywords

  • Contrast-enhanced ultrasound
  • Endocrine tumor
  • Enhanced ultrasound
  • Pancreatic adenocarcinoma
  • Pancreatic carcinoma
  • Pancreatic cystic tumors
  • Pancreatic ductal adenocarcinoma
  • Pancreatic tumors
  • Pseudocyst

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

D'Onofrio, M., Barbi, E., Dietrich, C. F., Kitano, M., Numata, K., Sofuni, A., ... Mucelli, R. P. (2012). Pancreatic multicenter ultrasound study (PAMUS). European Journal of Radiology, 81(4), 630-638. https://doi.org/10.1016/j.ejrad.2011.01.053

Pancreatic multicenter ultrasound study (PAMUS). / D'Onofrio, Mirko; Barbi, Emilio; Dietrich, Christoph F.; Kitano, Masayuki; Numata, Kazushi; Sofuni, Atsushi; Principe, Francesco; Gallotti, Anna; Zamboni, Giulia A.; Mucelli, Roberto Pozzi.

In: European Journal of Radiology, Vol. 81, No. 4, 04.2012, p. 630-638.

Research output: Contribution to journalArticle

D'Onofrio, M, Barbi, E, Dietrich, CF, Kitano, M, Numata, K, Sofuni, A, Principe, F, Gallotti, A, Zamboni, GA & Mucelli, RP 2012, 'Pancreatic multicenter ultrasound study (PAMUS)', European Journal of Radiology, vol. 81, no. 4, pp. 630-638. https://doi.org/10.1016/j.ejrad.2011.01.053
D'Onofrio M, Barbi E, Dietrich CF, Kitano M, Numata K, Sofuni A et al. Pancreatic multicenter ultrasound study (PAMUS). European Journal of Radiology. 2012 Apr;81(4):630-638. https://doi.org/10.1016/j.ejrad.2011.01.053
D'Onofrio, Mirko ; Barbi, Emilio ; Dietrich, Christoph F. ; Kitano, Masayuki ; Numata, Kazushi ; Sofuni, Atsushi ; Principe, Francesco ; Gallotti, Anna ; Zamboni, Giulia A. ; Mucelli, Roberto Pozzi. / Pancreatic multicenter ultrasound study (PAMUS). In: European Journal of Radiology. 2012 ; Vol. 81, No. 4. pp. 630-638.
@article{0b4aa60d4dd1496494fd3a96022f0b96,
title = "Pancreatic multicenter ultrasound study (PAMUS)",
abstract = "Aim: To describe the typical CEUS pattern of pancreatic lesions and to evaluate the diagnostic accuracy of Contrast-enhanced ultrasound (CEUS) in their characterization. Materials and methods: All US and CEUS examinations of focal pancreatic masses performed in six centers during a period of five years were reviewed. Inclusion criteria were: focal pancreatic mass pathologically proved, visible at ultrasound (US) and studied with CEUS. All lesions were then evaluated for size, aspect and enhancement pattern. Sensitivity, specificity, positive and negative predictive values with 95{\%} CIs were calculated to define diagnostic accuracy of CEUS in respect to pathology. Diagnostic confidence of US and CEUS, discerning between benign and malignant lesions, were represented by using ROC (receiver operating characteristics) curves. Agreement was evaluated by means of k statistics. Results: 1439 pancreatic lesions were included. At CEUS the lesions were divided into solid (89{\%}) and cystic (12{\%}) masses and classified into six and eight categories, respectively. Among the solid lesions, adenocarcinomas were characterized with an accuracy of 87.8{\%}. Among the cystic lesions, cystic tumors were diagnosed with an accuracy of 97.1{\%}. ROC curve area increased from 0.637 for US to 0.877 for CEUS (p <0.0001). Inter-observer agreement was slightly higher for solid (k = 0.78) than cystic (k = 0.62) lesions. In none of the centers side effects were reported. Conclusion: CEUS is accurate in the characterization of pancreatic lesions. CEUS should be considered as a complementary imaging method for pancreatic lesions characterization.",
keywords = "Contrast-enhanced ultrasound, Endocrine tumor, Enhanced ultrasound, Pancreatic adenocarcinoma, Pancreatic carcinoma, Pancreatic cystic tumors, Pancreatic ductal adenocarcinoma, Pancreatic tumors, Pseudocyst",
author = "Mirko D'Onofrio and Emilio Barbi and Dietrich, {Christoph F.} and Masayuki Kitano and Kazushi Numata and Atsushi Sofuni and Francesco Principe and Anna Gallotti and Zamboni, {Giulia A.} and Mucelli, {Roberto Pozzi}",
year = "2012",
month = "4",
doi = "10.1016/j.ejrad.2011.01.053",
language = "English",
volume = "81",
pages = "630--638",
journal = "European Journal of Radiology",
issn = "0720-048X",
publisher = "Elsevier Ireland Ltd",
number = "4",

}

TY - JOUR

T1 - Pancreatic multicenter ultrasound study (PAMUS)

AU - D'Onofrio, Mirko

AU - Barbi, Emilio

AU - Dietrich, Christoph F.

AU - Kitano, Masayuki

AU - Numata, Kazushi

AU - Sofuni, Atsushi

AU - Principe, Francesco

AU - Gallotti, Anna

AU - Zamboni, Giulia A.

AU - Mucelli, Roberto Pozzi

PY - 2012/4

Y1 - 2012/4

N2 - Aim: To describe the typical CEUS pattern of pancreatic lesions and to evaluate the diagnostic accuracy of Contrast-enhanced ultrasound (CEUS) in their characterization. Materials and methods: All US and CEUS examinations of focal pancreatic masses performed in six centers during a period of five years were reviewed. Inclusion criteria were: focal pancreatic mass pathologically proved, visible at ultrasound (US) and studied with CEUS. All lesions were then evaluated for size, aspect and enhancement pattern. Sensitivity, specificity, positive and negative predictive values with 95% CIs were calculated to define diagnostic accuracy of CEUS in respect to pathology. Diagnostic confidence of US and CEUS, discerning between benign and malignant lesions, were represented by using ROC (receiver operating characteristics) curves. Agreement was evaluated by means of k statistics. Results: 1439 pancreatic lesions were included. At CEUS the lesions were divided into solid (89%) and cystic (12%) masses and classified into six and eight categories, respectively. Among the solid lesions, adenocarcinomas were characterized with an accuracy of 87.8%. Among the cystic lesions, cystic tumors were diagnosed with an accuracy of 97.1%. ROC curve area increased from 0.637 for US to 0.877 for CEUS (p <0.0001). Inter-observer agreement was slightly higher for solid (k = 0.78) than cystic (k = 0.62) lesions. In none of the centers side effects were reported. Conclusion: CEUS is accurate in the characterization of pancreatic lesions. CEUS should be considered as a complementary imaging method for pancreatic lesions characterization.

AB - Aim: To describe the typical CEUS pattern of pancreatic lesions and to evaluate the diagnostic accuracy of Contrast-enhanced ultrasound (CEUS) in their characterization. Materials and methods: All US and CEUS examinations of focal pancreatic masses performed in six centers during a period of five years were reviewed. Inclusion criteria were: focal pancreatic mass pathologically proved, visible at ultrasound (US) and studied with CEUS. All lesions were then evaluated for size, aspect and enhancement pattern. Sensitivity, specificity, positive and negative predictive values with 95% CIs were calculated to define diagnostic accuracy of CEUS in respect to pathology. Diagnostic confidence of US and CEUS, discerning between benign and malignant lesions, were represented by using ROC (receiver operating characteristics) curves. Agreement was evaluated by means of k statistics. Results: 1439 pancreatic lesions were included. At CEUS the lesions were divided into solid (89%) and cystic (12%) masses and classified into six and eight categories, respectively. Among the solid lesions, adenocarcinomas were characterized with an accuracy of 87.8%. Among the cystic lesions, cystic tumors were diagnosed with an accuracy of 97.1%. ROC curve area increased from 0.637 for US to 0.877 for CEUS (p <0.0001). Inter-observer agreement was slightly higher for solid (k = 0.78) than cystic (k = 0.62) lesions. In none of the centers side effects were reported. Conclusion: CEUS is accurate in the characterization of pancreatic lesions. CEUS should be considered as a complementary imaging method for pancreatic lesions characterization.

KW - Contrast-enhanced ultrasound

KW - Endocrine tumor

KW - Enhanced ultrasound

KW - Pancreatic adenocarcinoma

KW - Pancreatic carcinoma

KW - Pancreatic cystic tumors

KW - Pancreatic ductal adenocarcinoma

KW - Pancreatic tumors

KW - Pseudocyst

UR - http://www.scopus.com/inward/record.url?scp=84858293404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858293404&partnerID=8YFLogxK

U2 - 10.1016/j.ejrad.2011.01.053

DO - 10.1016/j.ejrad.2011.01.053

M3 - Article

C2 - 21466935

AN - SCOPUS:84858293404

VL - 81

SP - 630

EP - 638

JO - European Journal of Radiology

JF - European Journal of Radiology

SN - 0720-048X

IS - 4

ER -