Pancreatic PEComa: A case report with ultrastructural localization of HMB-45 within melanosomes

Giovanna Finzi, Donata Micello, Giorgio Wizemann, Fausto Sessa, Carlo Capella

Research output: Contribution to journalArticlepeer-review

Abstract

PEComas (perivascular epithelioid cell tumors) represent a group of mesenchymal neoplasms showing characteristic morphologic, immunohistochemical, ultrastructural, and genetic features. These neoplasms are usually considered benign, being often well circumscribed by a thin capsule and showing scarce atypia. However, in some cases, they show local invasion and multiple metastases and cause the patient's death. PEComas have been found in many locations, but only 7 cases have been described in the pancreas to date. Here, the authors report an additional case of this rare neoplasm and demonstrate the HMB-45 immunoreactivity of melanosomes or premelanosomes at the ultrastructural level.

Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalUltrastructural Pathology
Volume36
Issue number2
DOIs
Publication statusPublished - Apr 2012

Keywords

  • HMB-45
  • Immunogold
  • Immunohistochemistry
  • Melanosome
  • Pancreas
  • PEComa
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology

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