TY - JOUR
T1 - Pancreatic PEComa
T2 - A case report with ultrastructural localization of HMB-45 within melanosomes
AU - Finzi, Giovanna
AU - Micello, Donata
AU - Wizemann, Giorgio
AU - Sessa, Fausto
AU - Capella, Carlo
PY - 2012/4
Y1 - 2012/4
N2 - PEComas (perivascular epithelioid cell tumors) represent a group of mesenchymal neoplasms showing characteristic morphologic, immunohistochemical, ultrastructural, and genetic features. These neoplasms are usually considered benign, being often well circumscribed by a thin capsule and showing scarce atypia. However, in some cases, they show local invasion and multiple metastases and cause the patient's death. PEComas have been found in many locations, but only 7 cases have been described in the pancreas to date. Here, the authors report an additional case of this rare neoplasm and demonstrate the HMB-45 immunoreactivity of melanosomes or premelanosomes at the ultrastructural level.
AB - PEComas (perivascular epithelioid cell tumors) represent a group of mesenchymal neoplasms showing characteristic morphologic, immunohistochemical, ultrastructural, and genetic features. These neoplasms are usually considered benign, being often well circumscribed by a thin capsule and showing scarce atypia. However, in some cases, they show local invasion and multiple metastases and cause the patient's death. PEComas have been found in many locations, but only 7 cases have been described in the pancreas to date. Here, the authors report an additional case of this rare neoplasm and demonstrate the HMB-45 immunoreactivity of melanosomes or premelanosomes at the ultrastructural level.
KW - HMB-45
KW - Immunogold
KW - Immunohistochemistry
KW - Melanosome
KW - Pancreas
KW - PEComa
KW - Ultrastructure
UR - http://www.scopus.com/inward/record.url?scp=84859312316&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859312316&partnerID=8YFLogxK
U2 - 10.3109/01913123.2011.642463
DO - 10.3109/01913123.2011.642463
M3 - Article
C2 - 22471435
AN - SCOPUS:84859312316
VL - 36
SP - 124
EP - 129
JO - Ultrastructural Pathology
JF - Ultrastructural Pathology
SN - 0191-3123
IS - 2
ER -