Pancreatic polypeptide (PP) cells in the PP-rich lobe of the human pancreas are identified ultrastructurally and immunocytochemically as F cells

R. Fiocca, F. Sessa, P. Tenti, L. Usellini, C. Capella, M. M T O'Hare, E. Solcia

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Abstract

The ultrastructure of immunohistochemically identified PP cells has been investigated by applying the serial semithin/thin section technique to the human pancreas, with special reference to the posterior part of the head, reputed to originate from the ventral primordium. PP cells of this area differ from those already identified in the rest of the pancreas and correspond to a cell, not yet described in the human pancreas, characterized by larger granules of very variable shape and structure. Such granules resemble those of so-called "F cells", i.e. the PP cells of dog uncinate process and cat duodenal lobe, also coming from the ventral primordium. Thus, human "ventral lobe" PP cells have peculiar potentialities which are expressed in distinctive structural patterns of presently unknown functional meaning.

Original languageEnglish
Pages (from-to)511-523
Number of pages13
JournalHistochemistry
Volume77
Issue number4
DOIs
Publication statusPublished - Dec 1983

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Pancreatic Polypeptide-Secreting Cells
Pancreatic Polypeptide
Pancreas
Cats
Head
Dogs

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  • Anatomy

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Pancreatic polypeptide (PP) cells in the PP-rich lobe of the human pancreas are identified ultrastructurally and immunocytochemically as F cells. / Fiocca, R.; Sessa, F.; Tenti, P.; Usellini, L.; Capella, C.; O'Hare, M. M T; Solcia, E.

In: Histochemistry, Vol. 77, No. 4, 12.1983, p. 511-523.

Research output: Contribution to journalArticle

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abstract = "The ultrastructure of immunohistochemically identified PP cells has been investigated by applying the serial semithin/thin section technique to the human pancreas, with special reference to the posterior part of the head, reputed to originate from the ventral primordium. PP cells of this area differ from those already identified in the rest of the pancreas and correspond to a cell, not yet described in the human pancreas, characterized by larger granules of very variable shape and structure. Such granules resemble those of so-called {"}F cells{"}, i.e. the PP cells of dog uncinate process and cat duodenal lobe, also coming from the ventral primordium. Thus, human {"}ventral lobe{"} PP cells have peculiar potentialities which are expressed in distinctive structural patterns of presently unknown functional meaning.",
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AU - Fiocca, R.

AU - Sessa, F.

AU - Tenti, P.

AU - Usellini, L.

AU - Capella, C.

AU - O'Hare, M. M T

AU - Solcia, E.

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