Pancreatic resection for metastases from renal cancer: Long term outcome after surgery and immunotherapy approach - Single center experience

Andrea Gardini, Paolo Morgagni, Carlo Milandri, Angela Riccobon, Ruggero Ridolfi, Giuliano La Barba, Luca Saragoni, Dino Amadori, Domenico Garcea

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aims: Natural history of renal cell carcinoma includes metastases to the pancreas. The literature reports that selected patients may have benefits by pancreatic resection in terms of long term survival. We report patient outcome and considerations on immunotherapy approach. Methodology: From 2001 to 2010 eight patients underwent pancreatic resection for metastases from renal cancer. We reviewed surgical outcome and following treatment (conventional chemotherapy: 5FU-Vindesine; Immunotherapy: Interleukin 2 - Interferon - Dendritic cells) of these patients. Results: All patients underwent radical pancreatic resection (7 spleno-pancreatectomies; 1 segmental pancreatic resection) and were R0 after surgery. No postoperative mortality was reported. Morbidity was 37% (2 distal leakage; 1 pneumonitis). Two patients did not receive any further treatment; 2 patients received conventional chemotherapy; 2 patients received immunotherapy (interleukin2 + interferon); 2 patients received dendritic cells (DC) interleukin-2 infusion. Three years overall survival rate was 55%. Disease free survival after 3 years was 30%. Conclusions: Our data confirm that pancreatic resection should be offered to selected patients with no mortality and low morbidity. Long-term survival is achievable, but recurrence rate after surgery is high. Immunotherapy could be effective to control tumour progression especially in selected cases where DC may be used.

Original languageEnglish
Pages (from-to)687-690
Number of pages4
JournalHepato-Gastroenterology
Volume59
Issue number115
DOIs
Publication statusPublished - May 2012

Keywords

  • Dendritic cells
  • Immunotherapy
  • Pancreatic resection
  • Renal cancer metastases

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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