Pancreatitis and cholecystitis in primary acute symptomatic Epstein-Barr virus infection – Systematic review of the literature

Lisa Kottanattu, Sebastiano A G Lava, Rossana Helbling, Giacomo D. Simonetti, Mario G. Bianchetti, Gregorio P. Milani

Research output: Contribution to journalReview articlepeer-review

Abstract

Acute pancreatitis and acalculous cholecystitis have been occasionally reported in primary acute symptomatic Epstein-Barr virus infection. We completed a review of the literature and retained 48 scientific reports published between 1966 and 2016 for the final analysis. Acute pancreatitis was recognized in 14 and acalculous cholecystitis in 37 patients with primary acute symptomatic Epstein-Barr virus infection. In all patients, the features of acute pancreatitis or acalculous cholecystitis concurrently developed with those of primary acute symptomatic Epstein-Barr virus infection. Acute pancreatitis and acalculous cholecystitis resolved following a hospital stay of 25 days or less. Acalculous cholecystitis was associated with Gilbert-Meulengracht syndrome in two cases. In conclusion, this thorough analysis indicates that acute pancreatitis and acalculous cholecystitis are unusual but plausible complications of primary acute symptomatic Epstein-Barr virus infection. Pancreatitis and cholecystitis deserve consideration in cases with severe abdominal pain. These complications are usually rather mild and resolve spontaneously without sequelae.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalJournal of Clinical Virology
Volume82
DOIs
Publication statusPublished - Sep 1 2016

Keywords

  • Acalculous cholecystitis
  • Epstein-Barr virus
  • Infectious mononucleosis
  • Pancreatitis

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Pancreatitis and cholecystitis in primary acute symptomatic Epstein-Barr virus infection – Systematic review of the literature'. Together they form a unique fingerprint.

Cite this