TY - JOUR
T1 - EFFICACIA E TOLLERABILITA DI PANTOPRAZOLO VS OMEPRAZOLE NELL'ULCERA DUODENALE. PRIMI RISULTATI DI UNO STUDIO MULTICENTRICO EUROPEO
AU - Porro, G. B.
AU - Lazzaroni, M.
AU - Cardelli, A.
AU - Gasperoni, S.
AU - De Berardinis, F.
AU - Delle Fave, G.
AU - Annibale, B.
AU - Galeazzi, R.
AU - Novelli, G.
AU - Mazzeo, F.
AU - Piccolo, P.
AU - Verme, G.
AU - Pera, A.
PY - 1994
Y1 - 1994
N2 - Aim - To evaluate the efficacy and tolerability of pantoprazole 40 mg s.i.d. in the treatment of duodenal ulcer, as compared to omeprazole 20 mg s.i.d. Materials and Methods - 96 patients affected by endoscopically-proven duodenal ulcer were randomly treated for 2-4 weeks. Ulcer healing rates and symptom improvement after therapy were evaluated as efficacy criteria. Results - After 2 weeks, ulcer was healed in 35 of 48 patients in the pantoprazole group, and in 30 of 48 in the omeprazole group (72.9% v.s. 62.5%, n.s.). At 4 weeks, corresponding figures were 47 and 44, respectively (97.9% vs 91.7%, n.s.). Among the patients who had ulcer pain prior to treatment, 34 of 40 in the pantoprazole group, and 35 of 40 in the omeprazole group were pain-free after 2 weeks (85% vs 87.5%, n.s.). The incidence of adverse events was comparable in the two groups (6% and 8%, respectively). Conclusions - Pantoprazole was shown to be a highly effective and well tolerated treatment for acute duodenal ulcer with respect both to ulcer healing and pain relief.
AB - Aim - To evaluate the efficacy and tolerability of pantoprazole 40 mg s.i.d. in the treatment of duodenal ulcer, as compared to omeprazole 20 mg s.i.d. Materials and Methods - 96 patients affected by endoscopically-proven duodenal ulcer were randomly treated for 2-4 weeks. Ulcer healing rates and symptom improvement after therapy were evaluated as efficacy criteria. Results - After 2 weeks, ulcer was healed in 35 of 48 patients in the pantoprazole group, and in 30 of 48 in the omeprazole group (72.9% v.s. 62.5%, n.s.). At 4 weeks, corresponding figures were 47 and 44, respectively (97.9% vs 91.7%, n.s.). Among the patients who had ulcer pain prior to treatment, 34 of 40 in the pantoprazole group, and 35 of 40 in the omeprazole group were pain-free after 2 weeks (85% vs 87.5%, n.s.). The incidence of adverse events was comparable in the two groups (6% and 8%, respectively). Conclusions - Pantoprazole was shown to be a highly effective and well tolerated treatment for acute duodenal ulcer with respect both to ulcer healing and pain relief.
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M3 - Articolo
AN - SCOPUS:0028672935
VL - 7
SP - 271
EP - 275
JO - Argomenti di Gastroenterologia Clinica
JF - Argomenti di Gastroenterologia Clinica
SN - 1120-8651
IS - 6
ER -