EFFICACIA E TOLLERABILITA DI PANTOPRAZOLO VS OMEPRAZOLE NELL'ULCERA DUODENALE. PRIMI RISULTATI DI UNO STUDIO MULTICENTRICO EUROPEO

Translated title of the contribution: Pantoprazole vs omeprazole in the treatment of duodenal ulcer

G. B. Porro, M. Lazzaroni, A. Cardelli, S. Gasperoni, F. De Berardinis, G. Delle Fave, B. Annibale, R. Galeazzi, G. Novelli, F. Mazzeo, P. Piccolo, G. Verme, A. Pera

Research output: Contribution to journalArticlepeer-review

Abstract

Aim - To evaluate the efficacy and tolerability of pantoprazole 40 mg s.i.d. in the treatment of duodenal ulcer, as compared to omeprazole 20 mg s.i.d. Materials and Methods - 96 patients affected by endoscopically-proven duodenal ulcer were randomly treated for 2-4 weeks. Ulcer healing rates and symptom improvement after therapy were evaluated as efficacy criteria. Results - After 2 weeks, ulcer was healed in 35 of 48 patients in the pantoprazole group, and in 30 of 48 in the omeprazole group (72.9% v.s. 62.5%, n.s.). At 4 weeks, corresponding figures were 47 and 44, respectively (97.9% vs 91.7%, n.s.). Among the patients who had ulcer pain prior to treatment, 34 of 40 in the pantoprazole group, and 35 of 40 in the omeprazole group were pain-free after 2 weeks (85% vs 87.5%, n.s.). The incidence of adverse events was comparable in the two groups (6% and 8%, respectively). Conclusions - Pantoprazole was shown to be a highly effective and well tolerated treatment for acute duodenal ulcer with respect both to ulcer healing and pain relief.

Translated title of the contributionPantoprazole vs omeprazole in the treatment of duodenal ulcer
Original languageItalian
Pages (from-to)271-275
Number of pages5
JournalArgomenti di Gastroenterologia Clinica
Volume7
Issue number6
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Gastroenterology

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