Papillary carcinoma of the thyroid gland of childhood and adolescence: Morphologic subtypes, biologic behavior and prognosis: A clinicopathologic study of 42 sporadic cases treated at a single institution during a 30-year period

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Papillary thyroid carcinomas (PTCs) in pediatric age show an excellent outcome, independently of sex, stage at diagnosis, occurrence of relapse, and type of treatment. Our aim was to study the biologic behavior and the impact on survival of PTC subtypes in childhood. From 1968 to 2002, 42 sporadic pediatric PTCs were subclassified into PTC, not otherwise specified and PTC variants. In all cases, sex, age at diagnosis, age of menarche, side, size, TNM/pTNM classification, neoplastic microfoci, vascular invasion, status of the non-neoplastic parenchyma, and treatment (surgery and nonsurgical therapies) were registered. Follow-up was carried on up to May 2005. PTC, solid/trabecular variant was the most frequent subtype. Both extrathyroid local invasion (P

Original languageEnglish
Pages (from-to)1420-1426
Number of pages7
JournalAmerican Journal of Surgical Pathology
Issue number11
Publication statusPublished - Nov 2006



  • Behavior
  • Children
  • Papillary carcinoma
  • Survival
  • Thyroid carcinoma
  • Variant

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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