Papillary glioneuronal tumor: Case report and literature review

Paolo Celli, Emanuela Caroli, Felice Giangaspero, Luigi Ferrante

Research output: Contribution to journalArticle


Objective and importance: Papillary glioneuronal tumor is a recently described neoplasm composed of gliovascular pseudopapillae associated with intervening neuronal cells ranging from neurocytes to ganglion cells. This tumor is not currently included in the WHO classification of tumors of the central nervous system. We describe a new case of papillary glioneuronal tumor and analyze the data for a series of further 15 patients from international literature. Clinical presentation: A 27-year-old man presented to us for generalized seizure. CT and MRI showed a cystic tumor with mural nodule in the left frontal lobe. Intervention: Frontal craniotomy with gross total removal of the tumor was performed. Histopathological examination was positive for papillary glioneuronal tumor. Conclusion: The clinical, radiologic, and pathological features of our case are strikingly similar to those of the previous reported cases. A review of the literature disclosed only 15 other cases of these tumors. Conclusion: It is important that every new case of PGNT is reported to allow its recognition and classification.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalJournal of Neuro-Oncology
Issue number2
Publication statusPublished - Nov 2006


  • Glial fibrillary acidic protein
  • Mixed glioneuronal tumor
  • Papillary pattern
  • Papillary tumor
  • Synaptophysin
  • WHO tumor classification

ASJC Scopus subject areas

  • Cancer Research
  • Clinical Neurology
  • Oncology
  • Neuroscience(all)

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