Papillary thyroid cancer in a struma ovarii: A report of a rare case

Eleonora Monti, Lorenzo Mortara, Simonetta Zupo, Mariella Dono, Francesco Minuto, Mauro Truini, Mehrdad Naseri, Massimo Giusti

Research output: Contribution to journalArticlepeer-review


After removal of an ovarian mass in a 43-year-old woman, a struma ovarii was diagnosed. Within this teratoma, a papillary thyroid cancer was found. The tumor was negative for BRAF, NRAS, KRAS, PIK3CA and c-KIT mutations on molecular analysis. Thyroid function and morphology were normal. Thyroidectomy, L-T4 TSH-suppressive therapy and rhTSH-induced radioiodine ablation were performed. So far, the follow-up has been favorable. This is the first case of thyroid cancer in a struma ovarii in which mutations of PIK3CA exons 9 and 20, and c-KIT exons 9, 11 and 13 have been evaluated and the third in which ablation has been performed under rhTSH. The prognosis of patients with thyroid cancer in a struma ovarii is generally poor. In our patient, as in those who undergo ablative radioactive iodine therapy, this was not the case.

Original languageEnglish
Pages (from-to)154-159
Number of pages6
Issue number1
Publication statusPublished - 2015


  • Papillary carcinoma
  • rhTSH
  • Struma ovarii
  • Teratoma

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)


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