Abstract
Epithelia permit selective and regulated flux from apical to basolateral surfaces by transcellular passage through cells or paracellular flux between cells. Tight junctions constitute the barrier to paracellular conductance; however, little is known about the specific molecules that mediate paracellular permeabilities. Renal magnesium ion (Mg2+) resorption occurs predominantly through a paracellular conductance in the thick ascending limb of Henle (TAL). Here, positional cloning has identified a human gene, paracellin-1 (PCLN-1), mutations on which cause renal Mg2+ wasting. PCLN-1 is located in tight junctions of the TAL and is related to the claudin family of tight junction proteins. These finding provide insight into Mg2+ homeostasis, demonstrate the role of a tight junction protein in human disease, and identify an essential component of selective paracellular conductance.
| Original language | English |
|---|---|
| Pages (from-to) | 103-106 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 285 |
| Issue number | 5424 |
| DOIs | |
| Publication status | Published - Jul 2 1999 |
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Cite this
Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. / Simon, David B.; Lu, Yin; Choate, Keith A.; Velazquez, Heino; Al-Sabban, Essam; Praga, Manuel; Casari, Giorgio; Bettinelli, Alberto; Colussi, Giacomo; Rodriguez-Soriano, Juan; McCredie, David; Milford, David; Sanjad, Sami; Lifton, Richard P.
In: Science, Vol. 285, No. 5424, 02.07.1999, p. 103-106.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption
AU - Simon, David B.
AU - Lu, Yin
AU - Choate, Keith A.
AU - Velazquez, Heino
AU - Al-Sabban, Essam
AU - Praga, Manuel
AU - Casari, Giorgio
AU - Bettinelli, Alberto
AU - Colussi, Giacomo
AU - Rodriguez-Soriano, Juan
AU - McCredie, David
AU - Milford, David
AU - Sanjad, Sami
AU - Lifton, Richard P.
PY - 1999/7/2
Y1 - 1999/7/2
N2 - Epithelia permit selective and regulated flux from apical to basolateral surfaces by transcellular passage through cells or paracellular flux between cells. Tight junctions constitute the barrier to paracellular conductance; however, little is known about the specific molecules that mediate paracellular permeabilities. Renal magnesium ion (Mg2+) resorption occurs predominantly through a paracellular conductance in the thick ascending limb of Henle (TAL). Here, positional cloning has identified a human gene, paracellin-1 (PCLN-1), mutations on which cause renal Mg2+ wasting. PCLN-1 is located in tight junctions of the TAL and is related to the claudin family of tight junction proteins. These finding provide insight into Mg2+ homeostasis, demonstrate the role of a tight junction protein in human disease, and identify an essential component of selective paracellular conductance.
AB - Epithelia permit selective and regulated flux from apical to basolateral surfaces by transcellular passage through cells or paracellular flux between cells. Tight junctions constitute the barrier to paracellular conductance; however, little is known about the specific molecules that mediate paracellular permeabilities. Renal magnesium ion (Mg2+) resorption occurs predominantly through a paracellular conductance in the thick ascending limb of Henle (TAL). Here, positional cloning has identified a human gene, paracellin-1 (PCLN-1), mutations on which cause renal Mg2+ wasting. PCLN-1 is located in tight junctions of the TAL and is related to the claudin family of tight junction proteins. These finding provide insight into Mg2+ homeostasis, demonstrate the role of a tight junction protein in human disease, and identify an essential component of selective paracellular conductance.
UR - http://www.scopus.com/inward/record.url?scp=0033516683&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033516683&partnerID=8YFLogxK
U2 - 10.1126/science.285.5424.103
DO - 10.1126/science.285.5424.103
M3 - Article
C2 - 10390358
AN - SCOPUS:0033516683
VL - 285
SP - 103
EP - 106
JO - Science
JF - Science
SN - 0036-8075
IS - 5424
ER -