TY - JOUR
T1 - Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption
AU - Simon, David B.
AU - Lu, Yin
AU - Choate, Keith A.
AU - Velazquez, Heino
AU - Al-Sabban, Essam
AU - Praga, Manuel
AU - Casari, Giorgio
AU - Bettinelli, Alberto
AU - Colussi, Giacomo
AU - Rodriguez-Soriano, Juan
AU - McCredie, David
AU - Milford, David
AU - Sanjad, Sami
AU - Lifton, Richard P.
PY - 1999/7/2
Y1 - 1999/7/2
N2 - Epithelia permit selective and regulated flux from apical to basolateral surfaces by transcellular passage through cells or paracellular flux between cells. Tight junctions constitute the barrier to paracellular conductance; however, little is known about the specific molecules that mediate paracellular permeabilities. Renal magnesium ion (Mg2+) resorption occurs predominantly through a paracellular conductance in the thick ascending limb of Henle (TAL). Here, positional cloning has identified a human gene, paracellin-1 (PCLN-1), mutations on which cause renal Mg2+ wasting. PCLN-1 is located in tight junctions of the TAL and is related to the claudin family of tight junction proteins. These finding provide insight into Mg2+ homeostasis, demonstrate the role of a tight junction protein in human disease, and identify an essential component of selective paracellular conductance.
AB - Epithelia permit selective and regulated flux from apical to basolateral surfaces by transcellular passage through cells or paracellular flux between cells. Tight junctions constitute the barrier to paracellular conductance; however, little is known about the specific molecules that mediate paracellular permeabilities. Renal magnesium ion (Mg2+) resorption occurs predominantly through a paracellular conductance in the thick ascending limb of Henle (TAL). Here, positional cloning has identified a human gene, paracellin-1 (PCLN-1), mutations on which cause renal Mg2+ wasting. PCLN-1 is located in tight junctions of the TAL and is related to the claudin family of tight junction proteins. These finding provide insight into Mg2+ homeostasis, demonstrate the role of a tight junction protein in human disease, and identify an essential component of selective paracellular conductance.
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U2 - 10.1126/science.285.5424.103
DO - 10.1126/science.285.5424.103
M3 - Article
C2 - 10390358
AN - SCOPUS:0033516683
VL - 285
SP - 103
EP - 106
JO - Science
JF - Science
SN - 0036-8075
IS - 5424
ER -