Paradoxical aging in HIV: Immune senescence of B Cells is most prominent in young age

Stefano Rinaldi, Suresh Pallikkuth, Varghese K. George, Lesley R. de Armas, Rajendra Pahwa, Celeste M. Sanchez, Maria Fernanda Pallin, Li Pan, Nicola Cotugno, Gordon Dickinson, Allan Rodriguez, Margaret Fischl, Maria Alcaide, Louis Gonzalez, Paolo Palma, Savita Pahwa

Research output: Contribution to journalArticlepeer-review


Combination antiretroviral therapies (cART) can lead to normal life expectancy in HIV-infected persons, and people aged > 50 yrs represent the fastest growing HIV group. Although HIV and aging are independently associated with impaired humoral immunity, immune status in people aging with HIV is relatively unexplored. In this study influenza vaccination was used to probe age associated perturbations in the B cell compartment of HIV-negative "healthy controls" (HC) and virologically controlled HIV-infected participants on cART (HIV) (n=124), grouped by age as young (< 40 yrs), middle-aged (40-59yrs) or old (≥ 60 yrs). H1N1 antibody response at d21 post-vaccination correlated inversely with age in both HC and HIV. Immunophenotyping of cryopreserved PBMC demonstrated increased frequencies of double negative B cells and decreased plasmablasts in old compared to young HC. Remarkably, young HIV were different from young HC but similar to old HC in B cell phenotype, influenza specific spontaneous (d7) or memory (d21) antibody secreting cells. We conclude that B cell immune senescence is a prominent phenomenon in young HIV in comparison to young HC, but distinctions between old HIV and old HC are less evident though both groups manifest age-associated B cell dysfunction.

Original languageEnglish
Pages (from-to)1307-1325
Number of pages19
Issue number4
Publication statusPublished - Jan 1 2017


  • Aging
  • B cells
  • Chronic infections
  • HIV
  • Immunosenescence
  • Influenza vaccination
  • PD1

ASJC Scopus subject areas

  • Ageing
  • Cell Biology


Dive into the research topics of 'Paradoxical aging in HIV: Immune senescence of B Cells is most prominent in young age'. Together they form a unique fingerprint.

Cite this