Paradoxical increase in microvascular resistance during tachycardia downstream from a severe stenosis in patients with coronary artery disease: Reversal by angioplasty

Gianmario Sambuceti, Mario Marzilli, Silvio Fedele, Cecilia Marini, Antonio L'Abbate

Research output: Contribution to journalArticle

Abstract

Background - The pathophysiology of microvascular response to a severe coronary stenosis has not been conclusively identified. The aim of this study was to characterize the human vasomotor response to pacing-induced ischemia of both the stenotic arterial segment and the distal microcirculation. Methods and Results - Sixteen patients with stable angina and single-vessel disease were studied. Blood flow velocity and transstenotic pressure gradient were monitored at baseline, after intracoronary adenosine (2 mg), and during ischemia induced by atrial pacing with and without adenosine. At the end of this protocol, the study was repeated after intracoronary phentolamine in 7 patients and after angioplasty in 9. Stenosis resistance was calculated as the ratio between mean pressure gradient and mean flow, and microvascular resistance as the ratio between mean distal pressure and mean flow; values were expressed as percent of baseline. Adenosine decreased (P

Original languageEnglish
Pages (from-to)2352-2360
Number of pages9
JournalCirculation
Volume103
Issue number19
Publication statusPublished - May 15 2001

Keywords

  • Blood flow
  • Circulation
  • Coronary disease
  • Microcirculation
  • Vasoconstriction

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Paradoxical increase in microvascular resistance during tachycardia downstream from a severe stenosis in patients with coronary artery disease: Reversal by angioplasty'. Together they form a unique fingerprint.

  • Cite this