Parafollicular C-cells of the thyroid are decreased in patients with congenital diaphragmatic hernia

A. L. Luis; F. Pederiva; J. L. Encinas; E. Ruiz; J. I. Rodriguez; L. Martinez; J. A. Tovar

doi:10.1055/s-0031-1273778

Parafollicular C-cells of the thyroid are decreased in patients with congenital diaphragmatic hernia

A. L. Luis, F. Pederiva, J. L. Encinas, E. Ruiz, J. I. Rodriguez, L. Martinez, J. A. Tovar

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Parathyroid and thymic anomalies related to embryonic neural crest dysfunction have been demonstrated in rats with congenital diaphragmatic hernia (CDH). These rats, like infants with CDH, have conotruncal, facial, and other neurocristal defects. The present study examines whether parafollicular C-cells (CC) of the thyroid, whose embryogenesis is related to that of the parathyroids and thymus, might also be abnormal in babies with CDH. Material and methods: Autopsy sections of the thyroids of 12 babies dead from CDH and of 11 controls were stained with anti-calcitonin antibodies. Calcitonin-stained areas and the histological distribution of CC within the thyroid gland were assessed. Mann-Whitney tests were used for comparison, with p

Original language	English
Pages (from-to)	246-249
Number of pages	4
Journal	European Journal of Pediatric Surgery
Volume	21
Issue number	4
DOIs	https://doi.org/10.1055/s-0031-1273778
Publication status	Published - 2011

Keywords

C-cell
calcitonin
congenital diaphragmatic hernia
human
thyroid

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Surgery

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10.1055/s-0031-1273778

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abstract = "Background: Parathyroid and thymic anomalies related to embryonic neural crest dysfunction have been demonstrated in rats with congenital diaphragmatic hernia (CDH). These rats, like infants with CDH, have conotruncal, facial, and other neurocristal defects. The present study examines whether parafollicular C-cells (CC) of the thyroid, whose embryogenesis is related to that of the parathyroids and thymus, might also be abnormal in babies with CDH. Material and methods: Autopsy sections of the thyroids of 12 babies dead from CDH and of 11 controls were stained with anti-calcitonin antibodies. Calcitonin-stained areas and the histological distribution of CC within the thyroid gland were assessed. Mann-Whitney tests were used for comparison, with p",

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AU - Luis, A. L.

AU - Pederiva, F.

AU - Encinas, J. L.

AU - Ruiz, E.

AU - Rodriguez, J. I.

AU - Martinez, L.

AU - Tovar, J. A.

PY - 2011

Y1 - 2011

N2 - Background: Parathyroid and thymic anomalies related to embryonic neural crest dysfunction have been demonstrated in rats with congenital diaphragmatic hernia (CDH). These rats, like infants with CDH, have conotruncal, facial, and other neurocristal defects. The present study examines whether parafollicular C-cells (CC) of the thyroid, whose embryogenesis is related to that of the parathyroids and thymus, might also be abnormal in babies with CDH. Material and methods: Autopsy sections of the thyroids of 12 babies dead from CDH and of 11 controls were stained with anti-calcitonin antibodies. Calcitonin-stained areas and the histological distribution of CC within the thyroid gland were assessed. Mann-Whitney tests were used for comparison, with p

AB - Background: Parathyroid and thymic anomalies related to embryonic neural crest dysfunction have been demonstrated in rats with congenital diaphragmatic hernia (CDH). These rats, like infants with CDH, have conotruncal, facial, and other neurocristal defects. The present study examines whether parafollicular C-cells (CC) of the thyroid, whose embryogenesis is related to that of the parathyroids and thymus, might also be abnormal in babies with CDH. Material and methods: Autopsy sections of the thyroids of 12 babies dead from CDH and of 11 controls were stained with anti-calcitonin antibodies. Calcitonin-stained areas and the histological distribution of CC within the thyroid gland were assessed. Mann-Whitney tests were used for comparison, with p

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