Abstract
Background: Parathyroid and thymic anomalies related to embryonic neural crest dysfunction have been demonstrated in rats with congenital diaphragmatic hernia (CDH). These rats, like infants with CDH, have conotruncal, facial, and other neurocristal defects. The present study examines whether parafollicular C-cells (CC) of the thyroid, whose embryogenesis is related to that of the parathyroids and thymus, might also be abnormal in babies with CDH. Material and methods: Autopsy sections of the thyroids of 12 babies dead from CDH and of 11 controls were stained with anti-calcitonin antibodies. Calcitonin-stained areas and the histological distribution of CC within the thyroid gland were assessed. Mann-Whitney tests were used for comparison, with p
Original language | English |
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Pages (from-to) | 246-249 |
Number of pages | 4 |
Journal | European Journal of Pediatric Surgery |
Volume | 21 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2011 |
Keywords
- C-cell
- calcitonin
- congenital diaphragmatic hernia
- human
- thyroid
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Surgery