Parafollicular C-cells of the thyroid are decreased in patients with congenital diaphragmatic hernia

A. L. Luis, F. Pederiva, J. L. Encinas, E. Ruiz, J. I. Rodriguez, L. Martinez, J. A. Tovar

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Parathyroid and thymic anomalies related to embryonic neural crest dysfunction have been demonstrated in rats with congenital diaphragmatic hernia (CDH). These rats, like infants with CDH, have conotruncal, facial, and other neurocristal defects. The present study examines whether parafollicular C-cells (CC) of the thyroid, whose embryogenesis is related to that of the parathyroids and thymus, might also be abnormal in babies with CDH. Material and methods: Autopsy sections of the thyroids of 12 babies dead from CDH and of 11 controls were stained with anti-calcitonin antibodies. Calcitonin-stained areas and the histological distribution of CC within the thyroid gland were assessed. Mann-Whitney tests were used for comparison, with p

Original languageEnglish
Pages (from-to)246-249
Number of pages4
JournalEuropean Journal of Pediatric Surgery
Volume21
Issue number4
DOIs
Publication statusPublished - 2011

Keywords

  • C-cell
  • calcitonin
  • congenital diaphragmatic hernia
  • human
  • thyroid

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

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