Abstract
Paragangliomas are highly vascular and predominantly benign neoplasms that have traditionally been treated by surgery, embolization and/or external beam radiotherapy (EBRT). The aim of this study is to evaluate the short-term local tumor control and safety of CyberKnife radiosurgery for these lesions. Nine patients, eight with jugular glomus paragangliomas and one with a carotid body paraganglioma, were treated. The target contouring was performed on merged CT and MR images. Eight patients were treated with doses ranging from 11 to 13 Gy (mean 12.5 Gy) in a single fraction and one with 24 Gy in three fractions prescribed to 72-83% isodose line. The mean follow-up was 20 months. One patient died from unrelated causes. There were no local recurrences. All eight patients also demonstrated neurological stability or improvement. Neither cranial nerve palsies have arisen, nor has deterioration beyond baseline been observed. In conclusion, CyberKnife radiosurgery appears to be both safe and effective in the treatment of skull base paragangliomas. Determining whether long-term complications will arise will require further investigation.
| Original language | English |
|---|---|
| Pages (from-to) | 479-485 |
| Number of pages | 7 |
| Journal | Neurological Sciences |
| Volume | 30 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2009 |
Fingerprint
Keywords
- CyberKnife
- Fractionated radiotherapy
- Paragangliomas
- Radiosurgery
ASJC Scopus subject areas
- Dermatology
- Clinical Neurology
- Psychiatry and Mental health
Cite this
Paragangliomas of head and neck : A treatment option with CyberKnife radiosurgery. / Bianchi, Livia C.; Marchetti, Marcello; Brait, Lorenzo; Bergantin, Achille; Milanesi, Ida; Broggi, Giovanni; Fariselli, Laura.
In: Neurological Sciences, Vol. 30, No. 6, 12.2009, p. 479-485.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Paragangliomas of head and neck
T2 - A treatment option with CyberKnife radiosurgery
AU - Bianchi, Livia C.
AU - Marchetti, Marcello
AU - Brait, Lorenzo
AU - Bergantin, Achille
AU - Milanesi, Ida
AU - Broggi, Giovanni
AU - Fariselli, Laura
PY - 2009/12
Y1 - 2009/12
N2 - Paragangliomas are highly vascular and predominantly benign neoplasms that have traditionally been treated by surgery, embolization and/or external beam radiotherapy (EBRT). The aim of this study is to evaluate the short-term local tumor control and safety of CyberKnife radiosurgery for these lesions. Nine patients, eight with jugular glomus paragangliomas and one with a carotid body paraganglioma, were treated. The target contouring was performed on merged CT and MR images. Eight patients were treated with doses ranging from 11 to 13 Gy (mean 12.5 Gy) in a single fraction and one with 24 Gy in three fractions prescribed to 72-83% isodose line. The mean follow-up was 20 months. One patient died from unrelated causes. There were no local recurrences. All eight patients also demonstrated neurological stability or improvement. Neither cranial nerve palsies have arisen, nor has deterioration beyond baseline been observed. In conclusion, CyberKnife radiosurgery appears to be both safe and effective in the treatment of skull base paragangliomas. Determining whether long-term complications will arise will require further investigation.
AB - Paragangliomas are highly vascular and predominantly benign neoplasms that have traditionally been treated by surgery, embolization and/or external beam radiotherapy (EBRT). The aim of this study is to evaluate the short-term local tumor control and safety of CyberKnife radiosurgery for these lesions. Nine patients, eight with jugular glomus paragangliomas and one with a carotid body paraganglioma, were treated. The target contouring was performed on merged CT and MR images. Eight patients were treated with doses ranging from 11 to 13 Gy (mean 12.5 Gy) in a single fraction and one with 24 Gy in three fractions prescribed to 72-83% isodose line. The mean follow-up was 20 months. One patient died from unrelated causes. There were no local recurrences. All eight patients also demonstrated neurological stability or improvement. Neither cranial nerve palsies have arisen, nor has deterioration beyond baseline been observed. In conclusion, CyberKnife radiosurgery appears to be both safe and effective in the treatment of skull base paragangliomas. Determining whether long-term complications will arise will require further investigation.
KW - CyberKnife
KW - Fractionated radiotherapy
KW - Paragangliomas
KW - Radiosurgery
UR - http://www.scopus.com/inward/record.url?scp=70449536499&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70449536499&partnerID=8YFLogxK
U2 - 10.1007/s10072-009-0138-3
DO - 10.1007/s10072-009-0138-3
M3 - Article
VL - 30
SP - 479
EP - 485
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 6
ER -