Parallel changes in resting muscle sympathetic nerve activity and blood pressure in a hypertensive OSAS patient demonstrate treatment efficacy

Vincenzo Donadio, Rocco Liguori, Roberto Vetrugno, Mikael Elam, Francesca Falzone, Agostino Baruzzi, Pasquale Montagna

Research output: Contribution to journalArticle


Studies comparing the efficacy of continuous positive airway pressure (CPAP) versus surgery in correcting cardiovascular abnormalities in OSAS are lacking. We describe an OSAS patient with hypertension who responded favorably to CPAP treatment, whereas subsequent uvulopalatopharyngoplasty (UPPP) was less successful. While CPAP markedly lowered daytime muscle sympathetic nerve activity (MSNA) and blood pressure (BP), findings after UPPP were comparable to pre-treatment baseline. Thus, parallel changes in MSNA and BP demonstrated treatment efficacy.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalClinical Autonomic Research
Issue number3
Publication statusPublished - Jun 2006



  • Blood pressure
  • Continuous positive airway pressure
  • Muscle sympathetic nerve activity
  • Obstructive sleep apnea syndrome
  • Uvulopalatopharyngoplasty

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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