Parallel strain-dependent susceptibility to environmentally-induced stereotypies and stress-induced behavioral sensitization in mice

Simona Cabib, Nunzio Bonaventura

Research output: Contribution to journalArticle

Abstract

Food restriction (9 days) promoted stereotyped behavior in drug-free mice of the DBA/2 (DBA), but not in those of the C57BL/6 (C57), inbred strain. Indeed, behavior presented by food-restricted mice of the DBA strain within the home cage was characterised by a very high response rate within a single response: cage cover climbing. Moreover, enhanced climbing in food-restricted mice of the DBA strain was also observed in a test designed to detect stereotypic effects of drugs in mice. Stereotypic behavior in DBA mice did not depend on nutritional status because: 1. No stereotypies were observed in DBA mice food-deprived for 15 h; 2. no strain-dependent differences in weight loss were observed; and 3. enhanced cage cover climbing was still evident in DBA mice following 24 h of free feeding. Finally, food-restricted DBA mice showed long-lasting sensitization to the locomotor effects of systemic amphetamine, indicating stress-induced behavioral sensitization in this strain of mice. By contrast, no sign of behavioral sensitization was observed in food-restricted mice of the C57 strain. These results indicate that restricted feeding promotes stereotyped behavior, as well as behavioral sensitization to amphetamine, in mice. Moreover, the observed parallelism between strain-dependent susceptibility to environmentally-induced stereotypies and behavioral sensitization supports the hypothesis that these phenomena share common neurobiological bases.

Original languageEnglish
Pages (from-to)499-506
Number of pages8
JournalPhysiology and Behavior
Volume61
Issue number4
DOIs
Publication statusPublished - Apr 1997

Keywords

  • Amphetamine
  • C57BL/6
  • Climbing
  • DBA/2
  • Dopamine
  • Food restriction
  • Inbred strains
  • Locomotion
  • Stereotypies
  • Stress

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

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