Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study

Pietro Maggi, Pascal Sati, Govind Nair, Irene C.M. Cortese, Steven Jacobson, Bryan R. Smith, Avindra Nath, Joan Ohayon, Vincent van Pesch, Gaetano Perrotta, Caroline Pot, Marie Théaudin, Vittorio Martinelli, Roberta Scotti, Tianxia Wu, Renaud Du Pasquier, Peter A. Calabresi, Massimo Filippi, Daniel S. Reich, Martina Absinta

Research output: Contribution to journalArticlepeer-review

Abstract

In multiple sclerosis (MS), a subset of chronic active white matter lesions are identifiable on magnetic resonance imaging by their paramagnetic rims, and increasing evidence supports their association with severity of clinical disease. We studied their potential role in differential diagnosis, screening an international multicenter clinical research-based sample of 438 individuals affected by different neurological conditions (MS, other inflammatory, infectious, and non-inflammatory conditions). Paramagnetic rim lesions, rare in other neurological conditions (52% of MS vs 7% of non-MS cases), yielded high specificity (93%) in differentiating MS from non-MS. Future prospective multicenter studies should validate their role as a diagnostic biomarker. ANN NEUROL 2020;88:1034–1042.

Original languageEnglish
Pages (from-to)1034-1042
Number of pages9
JournalAnnals of Neurology
Volume88
Issue number5
DOIs
Publication statusPublished - Nov 1 2020

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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