Parameters to monitor aging with a possible perspective for intervention - an immunological approach

Carlo Pieri, Rina Recchioni, Fausto Moroni, Marco Falasca, Sandor Damjanovich

Research output: Contribution to journalArticlepeer-review

Abstract

Reliable aging markers are very rare, which are better than the chronological age or those symptoms which have such great individual variability that their scientific value is questionable. The effect of aging on immunological behavior of human (and animal) individuals is reasonably well established. In this communication an attempt is made to find an immunological marker of aging at the level of cell surface phenomena. It was observed that ion-channel activities, having a complex regulation, loose their flexible responsiveness in lymphocyte membranes during aging. A recently discovered voltage regulation of the calcium-activated potassium channels showed a distinct change with aging of human lymphocytes. A possibility to find a better marker system in complex regulatory processes is also discussed.

Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalArchives of Gerontology and Geriatrics
Volume12
Issue number2-3
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

Fingerprint Dive into the research topics of 'Parameters to monitor aging with a possible perspective for intervention - an immunological approach'. Together they form a unique fingerprint.

Cite this