Abstract
Reliable aging markers are very rare, which are better than the chronological age or those symptoms which have such great individual variability that their scientific value is questionable. The effect of aging on immunological behavior of human (and animal) individuals is reasonably well established. In this communication an attempt is made to find an immunological marker of aging at the level of cell surface phenomena. It was observed that ion-channel activities, having a complex regulation, loose their flexible responsiveness in lymphocyte membranes during aging. A recently discovered voltage regulation of the calcium-activated potassium channels showed a distinct change with aging of human lymphocytes. A possibility to find a better marker system in complex regulatory processes is also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 231-238 |
| Number of pages | 8 |
| Journal | Archives of Gerontology and Geriatrics |
| Volume | 12 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 1991 |
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ASJC Scopus subject areas
- Ageing
- Medicine(all)
Cite this
Parameters to monitor aging with a possible perspective for intervention - an immunological approach. / Pieri, Carlo; Recchioni, Rina; Moroni, Fausto; Falasca, Marco; Damjanovich, Sandor.
In: Archives of Gerontology and Geriatrics, Vol. 12, No. 2-3, 1991, p. 231-238.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Parameters to monitor aging with a possible perspective for intervention - an immunological approach
AU - Pieri, Carlo
AU - Recchioni, Rina
AU - Moroni, Fausto
AU - Falasca, Marco
AU - Damjanovich, Sandor
PY - 1991
Y1 - 1991
N2 - Reliable aging markers are very rare, which are better than the chronological age or those symptoms which have such great individual variability that their scientific value is questionable. The effect of aging on immunological behavior of human (and animal) individuals is reasonably well established. In this communication an attempt is made to find an immunological marker of aging at the level of cell surface phenomena. It was observed that ion-channel activities, having a complex regulation, loose their flexible responsiveness in lymphocyte membranes during aging. A recently discovered voltage regulation of the calcium-activated potassium channels showed a distinct change with aging of human lymphocytes. A possibility to find a better marker system in complex regulatory processes is also discussed.
AB - Reliable aging markers are very rare, which are better than the chronological age or those symptoms which have such great individual variability that their scientific value is questionable. The effect of aging on immunological behavior of human (and animal) individuals is reasonably well established. In this communication an attempt is made to find an immunological marker of aging at the level of cell surface phenomena. It was observed that ion-channel activities, having a complex regulation, loose their flexible responsiveness in lymphocyte membranes during aging. A recently discovered voltage regulation of the calcium-activated potassium channels showed a distinct change with aging of human lymphocytes. A possibility to find a better marker system in complex regulatory processes is also discussed.
UR - http://www.scopus.com/inward/record.url?scp=0025740856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025740856&partnerID=8YFLogxK
U2 - 10.1016/0167-4943(91)90030-T
DO - 10.1016/0167-4943(91)90030-T
M3 - Article
AN - SCOPUS:0025740856
VL - 12
SP - 231
EP - 238
JO - Archives of Gerontology and Geriatrics
JF - Archives of Gerontology and Geriatrics
SN - 0167-4943
IS - 2-3
ER -