Parametric MR dynamic imaging for breast lesions characterization and prediction of lymph nodes involvement

Andrea Ciarmiello, Maria C. Gaeta, Martina Meniconi, Amalia Milano, Bruno Alfano, Silvana Del Vecchio, Marco Salvatore

Research output: Contribution to journalArticlepeer-review


The main purpose of this study was to evaluate Gd-DTPA kinetics for the differential diagnosis between malignant and benign breast lesions. As a secondary aim, Gd-DTPA kinetics in malignant lesions was tested for predicting axillary lymph nodes involvement. Eighty-eight patients who underwent MRI for suspected breast tumor were selected from our database. All patients underwent the same acquisition protocol consisting of pre-contrast and dynamic contrast-enhanced MRI. For all of them clinical and histopathological data were available. MR studies were performed on the same 1.5T scanner with a standard dedicated breast coil. Pre- and post-contrast dynamic images were used to calculate R1, R2 relaxation rates and proton density maps. The maximum influx rate (MIR) as well as the corresponding time (TMIR) were derived using R1 relaxation rate maps and relative changes as a function of time. Histopatological analysis led to the diagnosis of 46 breast carcinomas and 42 benign lesions. All breast carcinomas and 24 out of 42 benign lesions showed contrast-enhancement. The mean MIR was 0.75±0.14 (SD) sec-2 in malignant tumors and 0.53±0.14 (SD) sec-2 in contrast-enhancing benign breast lesions (p

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalCurrent Radiopharmaceuticals
Issue number2
Publication statusPublished - Oct 1 2014


  • Breast neoplasms
  • Contrast enhancement
  • Kinetic studies
  • Magnetic resonance (MR)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pharmacology
  • Medicine(all)


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