Paraneoplastic hypocalcemia-induced heart failure in advanced breast cancer: A case report and literature review

Alberto Farolfi, Cristiano Ferrario, Michele Aquilina, Lorenzo Cecconetto, Andreas Tartaglia, Toni Ibrahim, Luigi Serra, Devil Oboldi, Maurizio Nizzoli, Andrea Rocca

Research output: Contribution to journalArticlepeer-review

Abstract

Hypocalcemia is an uncommon clinical symptom of patients with malignant tumors, and a number of factors may be involved in its development. The present study describes the case of a 67-year-old Caucasian female, presenting with severe refractory hypocalcemia and heart failure. The patient was subsequently diagnosed with breast cancer and bone metastases. The paraneoplastic origin of the syndrome was confirmed by its complete resolution once the tumor responded to specific antineoplastic treatments, comprising weekly paclitaxel and aromatase inhibitor administration. The present case report suggested the need for greater awareness of the possibility of paraneoplastic hypocalcemia in breast cancer patients, and suggested that this condition may also contribute to the occurrence of heart failure. The mechanisms potentially responsible for this event were discussed and a brief review of the literature presented.

Original languageEnglish
Pages (from-to)773-777
Number of pages5
JournalOncology Letters
Volume10
Issue number2
DOIs
Publication statusPublished - 2015

Keywords

  • Bone metastasis
  • Breast cancer
  • Heart failure
  • Hypocalcemia
  • Paraneoplastic syndrome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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