Paraneoplastic pemphigoid-pemphigus? Subepidermal bullous disease with pemphigus-like direct immunofluorescence

F. Rongioletti, F. Truchetet, A. Rebora

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background. Paraneoplastic pemphigus is a recently described variant of pemphigus, in which classic immunologic features of pemphigus are associated with subepidermal erythema multiforme-like bullae. Case reports. Two patients with underlying malignant neoplasm had a bullous disease, which had clinical and histologic features suggestive of bullous pemphigoid while direct immunofluorescence revealed intercellular deposits of IgG and C3 throughout the malpighian layer of epidermis, a pattern usually diagnostic for pemphigus. Indirect immunofluorescence studies were negative. One mg/kg/day prednisone was enough to cure the eruption in a couple of weeks without any recurrence. Conclusions. The disease differs from the recently reported paraneoplastic pemphigus and from other bullous diseases associating circulating pemphigus-like antibodies with clinical, histologic, and often even immunologic features of bullous pemphigoid.

Original languageEnglish
Pages (from-to)48-51
Number of pages4
JournalInternational Journal of Dermatology
Volume32
Issue number1
Publication statusPublished - 1993

Fingerprint

Bullous Pemphigoid
Direct Fluorescent Antibody Technique
Pemphigus
Erythema Multiforme
Blister
Indirect Fluorescent Antibody Technique
Prednisone
Epidermis
Immunoglobulin G
Recurrence
Antibodies
Neoplasms

ASJC Scopus subject areas

  • Dermatology

Cite this

Paraneoplastic pemphigoid-pemphigus? Subepidermal bullous disease with pemphigus-like direct immunofluorescence. / Rongioletti, F.; Truchetet, F.; Rebora, A.

In: International Journal of Dermatology, Vol. 32, No. 1, 1993, p. 48-51.

Research output: Contribution to journalArticle

@article{0fe27960c0464d98b73e304305ddc7ae,
title = "Paraneoplastic pemphigoid-pemphigus? Subepidermal bullous disease with pemphigus-like direct immunofluorescence",
abstract = "Background. Paraneoplastic pemphigus is a recently described variant of pemphigus, in which classic immunologic features of pemphigus are associated with subepidermal erythema multiforme-like bullae. Case reports. Two patients with underlying malignant neoplasm had a bullous disease, which had clinical and histologic features suggestive of bullous pemphigoid while direct immunofluorescence revealed intercellular deposits of IgG and C3 throughout the malpighian layer of epidermis, a pattern usually diagnostic for pemphigus. Indirect immunofluorescence studies were negative. One mg/kg/day prednisone was enough to cure the eruption in a couple of weeks without any recurrence. Conclusions. The disease differs from the recently reported paraneoplastic pemphigus and from other bullous diseases associating circulating pemphigus-like antibodies with clinical, histologic, and often even immunologic features of bullous pemphigoid.",
author = "F. Rongioletti and F. Truchetet and A. Rebora",
year = "1993",
language = "English",
volume = "32",
pages = "48--51",
journal = "International Journal of Dermatology",
issn = "0011-9059",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Paraneoplastic pemphigoid-pemphigus? Subepidermal bullous disease with pemphigus-like direct immunofluorescence

AU - Rongioletti, F.

AU - Truchetet, F.

AU - Rebora, A.

PY - 1993

Y1 - 1993

N2 - Background. Paraneoplastic pemphigus is a recently described variant of pemphigus, in which classic immunologic features of pemphigus are associated with subepidermal erythema multiforme-like bullae. Case reports. Two patients with underlying malignant neoplasm had a bullous disease, which had clinical and histologic features suggestive of bullous pemphigoid while direct immunofluorescence revealed intercellular deposits of IgG and C3 throughout the malpighian layer of epidermis, a pattern usually diagnostic for pemphigus. Indirect immunofluorescence studies were negative. One mg/kg/day prednisone was enough to cure the eruption in a couple of weeks without any recurrence. Conclusions. The disease differs from the recently reported paraneoplastic pemphigus and from other bullous diseases associating circulating pemphigus-like antibodies with clinical, histologic, and often even immunologic features of bullous pemphigoid.

AB - Background. Paraneoplastic pemphigus is a recently described variant of pemphigus, in which classic immunologic features of pemphigus are associated with subepidermal erythema multiforme-like bullae. Case reports. Two patients with underlying malignant neoplasm had a bullous disease, which had clinical and histologic features suggestive of bullous pemphigoid while direct immunofluorescence revealed intercellular deposits of IgG and C3 throughout the malpighian layer of epidermis, a pattern usually diagnostic for pemphigus. Indirect immunofluorescence studies were negative. One mg/kg/day prednisone was enough to cure the eruption in a couple of weeks without any recurrence. Conclusions. The disease differs from the recently reported paraneoplastic pemphigus and from other bullous diseases associating circulating pemphigus-like antibodies with clinical, histologic, and often even immunologic features of bullous pemphigoid.

UR - http://www.scopus.com/inward/record.url?scp=0027407828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027407828&partnerID=8YFLogxK

M3 - Article

VL - 32

SP - 48

EP - 51

JO - International Journal of Dermatology

JF - International Journal of Dermatology

SN - 0011-9059

IS - 1

ER -