Paraneoplastic syndrome - unresponsive systemic hypertension and fever as expression of primitive ciliary body carcinoma in a blind painful eye: A case report

Laura Balia, Paolo Vinciguerra, Alessandra Di Maria, Raffaele Piscopo, Mary Romano

Research output: Contribution to journalArticle

Abstract

Background: The purpose of this study was to present a case of paraneoplastic systemic hypertension and fever in an undiagnosed primary ciliary body carcinoma arising in a painful blind eye. Case presentation: A 37-year-old white man with a history of blindness since childhood was enucleated for neovascular glaucoma because of intractable pain in his right eye. A histopathological examination revealed a ciliary body carcinoma. One year later, an invasive recurrence of his orbit and ethmoid was detected and a debulking procedure was performed. He had untreatable fever and multidrug-resistant systemic hypertension for 3 months before the neoplasm diagnosis. He recovered from fever and systemic hypertension only after tumor excision and relapsed 1 year later when synchronous tumor dissemination was shown through a computed tomography scan. Tumor metastases, despite surgery and chemotherapy, caused his death. Conclusions: Paraneoplastic symptoms such as fever and hypertension may be due to unrecognized ocular malignancy. This case report intends to emphasize the importance of histopathological examination of an enucleated phthisical painful blind eye.

Original languageEnglish
JournalJournal of Medical Case Reports
DOIs
Publication statusAccepted/In press - Jan 18 2016

Keywords

  • Cancer
  • Ciliary body carcinoma
  • Systemic hypertension

ASJC Scopus subject areas

  • Medicine(all)

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