Paraoxonases, eicosanoids and their role in age related diseases

Research output: Chapter in Book/Report/Conference proceedingChapter


The Paraoxonase family represents one of the most important classes of enzymesresponsible for the protection against oxidative damage and lipid peroxidation. It iscomposed by three members: PON1, PON2 and PON3 that show high similarity in theirstructural characteristics. PON1 and PON3 are active in the serum where they areassociated with HDL. On the other hand, PON2 is not detectable in serum but expressedin several tissues. These enzymes have been extensively studied especially for theirability to counteract oxidative stress and ameliorate atherosclerosis. Together withparaoxonases, eicosanoids are involved in the pathway underlying the reactive oxygenspecies (ROS) production and are considered key players in the atherosclerosis process.The topic of this chapter is to focus on the relationship between eicosanoids andparaoxonases and their involvement in the onset of age related diseases, especiallycardiovascular diseases

Original languageEnglish
Title of host publicationEicosanoids, Inflammation and Chronic Inflammatory Diseases: Pathophysiology, Health Effects and Targets for Therapies
PublisherNova Science Publishers, Inc.
Number of pages8
ISBN (Print)9781634828420, 9781634827997
Publication statusPublished - Jan 1 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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