Parasympathetic stimuli on bronchial and cardiovascular systems in humans

Emanuela Zannin, Riccardo Pellegrino, Alessandro Di Toro, Andrea Antonelli, Raffaele L. Dellacà, Luciano Bernardi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: It is not known whether parasympathetic outflow simultaneously acts on bronchial tone and cardiovascular system waxing and waning both systems in parallel, or, alternatively, whether the regulation is more dependent on local factors and therefore independent on each system. The aim of this study was to evaluate the simultaneous effect of different kinds of stimulations, all associated with parasympathetic activation, on bronchomotor tone and cardiovascular autonomic regulation. Methods: Respiratory system resistance (Rrs, forced oscillation technique) and cardio-vascular activity (heart rate, oxygen saturation, tissue oxygenation index, blood pressure) were assessed in 13 volunteers at baseline and during a series of parasympathetic stimuli: O2 inhalation, stimulation of the carotid sinus baroreceptors by neck suction, slow breathing, and inhalation of methacholine. Results: Pure cholinergic stimuli, like O2 inhalation and baroreceptors stimulation, caused an increase in Rrs and a reduction in heart rate and blood pressure. Slow breathing led to bradycardia and hypotension, without significant changes in Rrs. However slow breathing was associated with deep inhalations, and Rrs evaluated at the baseline lung volumes was significantly increased, suggesting that the large tidal volumes reversed the airways narrowing effect of parasympathetic activation. Finally inhaled methacholine caused marked airway narrowing, while the cardiovascular variables were unaffected, presumably because of the sympathetic activity triggered in response to hypoxemia. Conclusions: All parasympathetic stimuli affected bronchial tone and moderately affected also the cardiovascular system. However the response differed depending on the nature of the stimulus. Slow breathing was associated with large tidal volumes that reversed the airways narrowing effect of parasympathetic activation.

Original languageEnglish
Article numbere0127697
JournalPLoS One
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 5 2015

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Cardiovascular system
cardiovascular system
Cardiovascular System
Inhalation
breathing
Respiration
Methacholine Chloride
Chemical activation
Blood pressure
Pressoreceptors
Tidal Volume
Respiratory system
Oxygenation
Heart Rate
Blood Pressure
Carotid Sinus
tidal volume
Cholinergic Agents
Suction
Bradycardia

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Zannin, E., Pellegrino, R., Di Toro, A., Antonelli, A., Dellacà, R. L., & Bernardi, L. (2015). Parasympathetic stimuli on bronchial and cardiovascular systems in humans. PLoS One, 10(6), [e0127697]. https://doi.org/10.1371/journal.pone.0127697

Parasympathetic stimuli on bronchial and cardiovascular systems in humans. / Zannin, Emanuela; Pellegrino, Riccardo; Di Toro, Alessandro; Antonelli, Andrea; Dellacà, Raffaele L.; Bernardi, Luciano.

In: PLoS One, Vol. 10, No. 6, e0127697, 05.06.2015.

Research output: Contribution to journalArticle

Zannin, E, Pellegrino, R, Di Toro, A, Antonelli, A, Dellacà, RL & Bernardi, L 2015, 'Parasympathetic stimuli on bronchial and cardiovascular systems in humans', PLoS One, vol. 10, no. 6, e0127697. https://doi.org/10.1371/journal.pone.0127697
Zannin E, Pellegrino R, Di Toro A, Antonelli A, Dellacà RL, Bernardi L. Parasympathetic stimuli on bronchial and cardiovascular systems in humans. PLoS One. 2015 Jun 5;10(6). e0127697. https://doi.org/10.1371/journal.pone.0127697
Zannin, Emanuela ; Pellegrino, Riccardo ; Di Toro, Alessandro ; Antonelli, Andrea ; Dellacà, Raffaele L. ; Bernardi, Luciano. / Parasympathetic stimuli on bronchial and cardiovascular systems in humans. In: PLoS One. 2015 ; Vol. 10, No. 6.
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