PARATHYROID HORMONE INHIBITS HUMAN PLATELET FUNCTION

G. Remuzzi, P. Dodesini, M. Livio, G. Mecca, A. Benigni, A. Schieppati, E. Poletti, G. De Gaetano

Research output: Contribution to journalArticlepeer-review

Abstract

Several inhibitors of platelet function have been found in blood from uraemic patients. It has been suggested that parathyroid hormone (PTH) is a major uraemic toxin underlying many manifestations of the uraemic syndrome. Two different preparations of PTH strongly inhibited human platelet aggregation and secretion induced in vitro by different stimuli. The data suggest one possible pathway for the participation of excess PTH in the pathogenesis of the platelet dysfunction and bleeding tendency in uraemia.

Original languageEnglish
Pages (from-to)1321-1323
Number of pages3
JournalLancet
Volume318
Issue number8259
DOIs
Publication statusPublished - Dec 12 1981

ASJC Scopus subject areas

  • Medicine(all)

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