PARATHYROID HORMONE INHIBITS HUMAN PLATELET FUNCTION

G. Remuzzi; P. Dodesini; M. Livio; G. Mecca; A. Benigni; A. Schieppati; E. Poletti; G. De Gaetano

doi:10.1016/S0140-6736(81)91343-X

PARATHYROID HORMONE INHIBITS HUMAN PLATELET FUNCTION

G. Remuzzi, P. Dodesini, M. Livio, G. Mecca, A. Benigni, A. Schieppati, E. Poletti, G. De Gaetano

Research output: Contribution to journal › Article › peer-review

Abstract

Several inhibitors of platelet function have been found in blood from uraemic patients. It has been suggested that parathyroid hormone (PTH) is a major uraemic toxin underlying many manifestations of the uraemic syndrome. Two different preparations of PTH strongly inhibited human platelet aggregation and secretion induced in vitro by different stimuli. The data suggest one possible pathway for the participation of excess PTH in the pathogenesis of the platelet dysfunction and bleeding tendency in uraemia.

Original language	English
Pages (from-to)	1321-1323
Number of pages	3
Journal	Lancet
Volume	318
Issue number	8259
DOIs	https://doi.org/10.1016/S0140-6736(81)91343-X
Publication status	Published - Dec 12 1981

ASJC Scopus subject areas

Medicine(all)

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title = "PARATHYROID HORMONE INHIBITS HUMAN PLATELET FUNCTION",

abstract = "Several inhibitors of platelet function have been found in blood from uraemic patients. It has been suggested that parathyroid hormone (PTH) is a major uraemic toxin underlying many manifestations of the uraemic syndrome. Two different preparations of PTH strongly inhibited human platelet aggregation and secretion induced in vitro by different stimuli. The data suggest one possible pathway for the participation of excess PTH in the pathogenesis of the platelet dysfunction and bleeding tendency in uraemia.",

author = "G. Remuzzi and P. Dodesini and M. Livio and G. Mecca and A. Benigni and A. Schieppati and E. Poletti and {De Gaetano}, G.",

year = "1981",

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doi = "10.1016/S0140-6736(81)91343-X",

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AU - Remuzzi, G.

AU - Dodesini, P.

AU - Livio, M.

AU - Mecca, G.

AU - Benigni, A.

AU - Schieppati, A.

AU - Poletti, E.

AU - De Gaetano, G.

PY - 1981/12/12

Y1 - 1981/12/12

N2 - Several inhibitors of platelet function have been found in blood from uraemic patients. It has been suggested that parathyroid hormone (PTH) is a major uraemic toxin underlying many manifestations of the uraemic syndrome. Two different preparations of PTH strongly inhibited human platelet aggregation and secretion induced in vitro by different stimuli. The data suggest one possible pathway for the participation of excess PTH in the pathogenesis of the platelet dysfunction and bleeding tendency in uraemia.

AB - Several inhibitors of platelet function have been found in blood from uraemic patients. It has been suggested that parathyroid hormone (PTH) is a major uraemic toxin underlying many manifestations of the uraemic syndrome. Two different preparations of PTH strongly inhibited human platelet aggregation and secretion induced in vitro by different stimuli. The data suggest one possible pathway for the participation of excess PTH in the pathogenesis of the platelet dysfunction and bleeding tendency in uraemia.

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JO - The Lancet

JF - The Lancet

SN - 0140-6736

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ER -

PARATHYROID HORMONE INHIBITS HUMAN PLATELET FUNCTION

Abstract

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