Several inhibitors of platelet function have been found in blood from uraemic patients. It has been suggested that parathyroid hormone (PTH) is a major uraemic toxin underlying many manifestations of the uraemic syndrome. Two different preparations of PTH strongly inhibited human platelet aggregation and secretion induced in vitro by different stimuli. The data suggest one possible pathway for the participation of excess PTH in the pathogenesis of the platelet dysfunction and bleeding tendency in uraemia.
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