Abstract
The parathyroid hormone-related peptide (PTHrP) has been shown to be the major pathogenic factor to humoral hypercalcemia of malignancy (HHM). The presence of PTHrP in many normal tissues and in normal or abnormal parathyroids has been described in literature and its role has been investigated. PTHrP release from parathyroid cells into the extracellular space has been demonstrated to depend on the extracellular calcium concentration. The hormone binds to PTH type 1 Receptor (PTH1R) with a high affinity, as well as parathyroid hormone (PTH). These hormones' amino-terminal (1-34) peptide fragments are considered sufficient to achieve efficient receptor activation and action on mineral ion homeostasis. Generally, diagnosis of primary hyperparathyroidism (PHPT) is based on hypercalcaemia and elevated levels of PTH. The advent of intact-PTH immunoradiometric assay allowed us to distinguish PHPT from non-parathyroid-dependent hypercalcaemia, but the presentation of normal PTH level and hypercalcaemia due to a parathyroid adenoma is possible. The aim of the study is to identify the relationship between the production of PTHrP without malignancy and the diagnosis of PHPT by a systematic review.
| Original language | English |
|---|---|
| Pages (from-to) | 299-312 |
| Number of pages | 14 |
| Journal | Frontiers in Bioscience - Scholar |
| Volume | 2 S |
| Issue number | 1 |
| Publication status | Published - Jan 1 2010 |
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Keywords
- Hypercalcaemia
- Parathyroid Adenoma
- Primary Hyperparathyroidism
- PTH
- PTHrP
- Review
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Medicine(all)
Cite this
Parathyroid hormone-related peptide and primary hyperparathyroidism. / Testini, Mario; Gurrado, Angela; Lissidini, Germana; Piccinni, Giuseppe; Greco, Luigi; Basile, Francesco; Biondi, Antonio.
In: Frontiers in Bioscience - Scholar, Vol. 2 S, No. 1, 01.01.2010, p. 299-312.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Parathyroid hormone-related peptide and primary hyperparathyroidism
AU - Testini, Mario
AU - Gurrado, Angela
AU - Lissidini, Germana
AU - Piccinni, Giuseppe
AU - Greco, Luigi
AU - Basile, Francesco
AU - Biondi, Antonio
PY - 2010/1/1
Y1 - 2010/1/1
N2 - The parathyroid hormone-related peptide (PTHrP) has been shown to be the major pathogenic factor to humoral hypercalcemia of malignancy (HHM). The presence of PTHrP in many normal tissues and in normal or abnormal parathyroids has been described in literature and its role has been investigated. PTHrP release from parathyroid cells into the extracellular space has been demonstrated to depend on the extracellular calcium concentration. The hormone binds to PTH type 1 Receptor (PTH1R) with a high affinity, as well as parathyroid hormone (PTH). These hormones' amino-terminal (1-34) peptide fragments are considered sufficient to achieve efficient receptor activation and action on mineral ion homeostasis. Generally, diagnosis of primary hyperparathyroidism (PHPT) is based on hypercalcaemia and elevated levels of PTH. The advent of intact-PTH immunoradiometric assay allowed us to distinguish PHPT from non-parathyroid-dependent hypercalcaemia, but the presentation of normal PTH level and hypercalcaemia due to a parathyroid adenoma is possible. The aim of the study is to identify the relationship between the production of PTHrP without malignancy and the diagnosis of PHPT by a systematic review.
AB - The parathyroid hormone-related peptide (PTHrP) has been shown to be the major pathogenic factor to humoral hypercalcemia of malignancy (HHM). The presence of PTHrP in many normal tissues and in normal or abnormal parathyroids has been described in literature and its role has been investigated. PTHrP release from parathyroid cells into the extracellular space has been demonstrated to depend on the extracellular calcium concentration. The hormone binds to PTH type 1 Receptor (PTH1R) with a high affinity, as well as parathyroid hormone (PTH). These hormones' amino-terminal (1-34) peptide fragments are considered sufficient to achieve efficient receptor activation and action on mineral ion homeostasis. Generally, diagnosis of primary hyperparathyroidism (PHPT) is based on hypercalcaemia and elevated levels of PTH. The advent of intact-PTH immunoradiometric assay allowed us to distinguish PHPT from non-parathyroid-dependent hypercalcaemia, but the presentation of normal PTH level and hypercalcaemia due to a parathyroid adenoma is possible. The aim of the study is to identify the relationship between the production of PTHrP without malignancy and the diagnosis of PHPT by a systematic review.
KW - Hypercalcaemia
KW - Parathyroid Adenoma
KW - Primary Hyperparathyroidism
KW - PTH
KW - PTHrP
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=77957301899&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957301899&partnerID=8YFLogxK
M3 - Article
VL - 2 S
SP - 299
EP - 312
JO - Frontiers in Bioscience - Scholar
JF - Frontiers in Bioscience - Scholar
SN - 1945-0516
IS - 1
ER -