Parathyroid Tumor Microenvironment

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Parathyroid tumors are the second most common endocrine neoplasia, and it is almost always associated with hypersecretion of the parathormone (PTH), involved in calcium homeostasis, causing primary hyperparathyroidism (PHPT). Parathyroid neoplasia has a stromal component particularly represented in atypical adenomatous and carcinomatous lesions. Recently, data about the features and the function of the parathyroid tumor microenvironment (TME) have been accumulated. Parathyroid TME includes heterogeneous cells: endothelial cells, myofibroblasts, lymphocytes and macrophages, and mesenchymal stem cells have been identified, each of them presenting a phenotype consistent with tumor-associated cells. Parathyroid tumors overexpress proangiogenic molecules including vascular endothelial growth factor (VEGF-A), fibroblast growth factor-2 (FGF-2), and angiopoietins that promote both recruitment and proliferation of endothelial cell precursors, thus resulting in a microvessel density higher than that detected in normal parathyroid glands. Moreover, parathyroid tumor endocrine cells operate multifaceted interactions with stromal cells, partly mediated by the CXCL12/CXCR4 pathway, while, at present, the immune landscape of parathyroid tumors has just begun to be investigated. Studies about TME in parathyroid adenomas provide an example of the role of TME in benign tumors, whose molecular mechanisms and functions comprehension are limited.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages37-50
Number of pages14
DOIs
Publication statusPublished - Jan 1 2020

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1226
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • CD31
  • CD34
  • Collagen matrix
  • CXCR4
  • Parathyroid adenomas
  • Parathyroid carcinomas
  • Parathyroid tumors
  • Primary hyperparathyroidism
  • PTH
  • SDF-1/CXCL12
  • Tumor-associated endothelial cells
  • Tumor-associated macrophages
  • Tumor-associated myofibroblasts
  • Tumor-infiltrating lymphocytes
  • VEGF-A
  • α-SMA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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