Parathyroid Tumor Microenvironment: Advances in Experimental Medicine and Biology

C. Verdelli, V. Vaira, S. Corbetta

Research output: Book/ReportBook

Abstract

Parathyroid tumors are the second most common endocrine neoplasia, and it is almost always associated with hypersecretion of the parathormone (PTH), involved in calcium homeostasis, causing primary hyperparathyroidism (PHPT). Parathyroid neoplasia has a stromal component particularly represented in atypical adenomatous and carcinomatous lesions. Recently, data about the features and the function of the parathyroid tumor microenvironment (TME) have been accumulated. Parathyroid TME includes heterogeneous cells: endothelial cells, myofibroblasts, lymphocytes and macrophages, and mesenchymal stem cells have been identified, each of them presenting a phenotype consistent with tumor-associated cells. Parathyroid tumors overexpress proangiogenic molecules including vascular endothelial growth factor (VEGF-A), fibroblast growth factor-2 (FGF-2), and angiopoietins that promote both recruitment and proliferation of endothelial cell precursors, thus resulting in a microvessel density higher than that detected in normal parathyroid glands. Moreover, parathyroid tumor endocrine cells operate multifaceted interactions with stromal cells, partly mediated by the CXCL12/CXCR4 pathway, while, at present, the immune landscape of parathyroid tumors has just begun to be investigated. Studies about TME in parathyroid adenomas provide an example of the role of TME in benign tumors, whose molecular mechanisms and functions comprehension are limited. © 2020, Springer Nature Switzerland AG.
Original languageEnglish
PublisherSpringer
Number of pages14
Volume1226
ISBN (Print)00652598 (ISSN)
DOIs
Publication statusPublished - 2020

Keywords

  • CD31
  • CD34
  • Collagen matrix
  • CXCR4
  • Parathyroid adenomas
  • Parathyroid carcinomas
  • Parathyroid tumors
  • Primary hyperparathyroidism
  • PTH
  • SDF-1/CXCL12
  • Tumor-associated endothelial cells
  • Tumor-associated macrophages
  • Tumor-associated myofibroblasts
  • Tumor-infiltrating lymphocytes
  • VEGF-A
  • α-SMA
  • angiopoietin
  • chemokine receptor CXCR4
  • fibroblast growth factor 2
  • microRNA
  • parathyroid hormone
  • stromal cell derived factor 1
  • vasculotropin A
  • angiogenesis
  • calcium homeostasis
  • cancer associated fibroblast
  • carcinogenesis
  • cell interaction
  • cell proliferation
  • histology
  • human
  • inflammatory infiltrate
  • lymphangiogenesis
  • mesenchymal stem cell
  • myofibroblast
  • parathyroid hormone release
  • parathyroid tumor
  • primary hyperparathyroidism
  • priority journal
  • tumor microenvironment
  • tumor vascularization
  • metabolism
  • parathyroid gland
  • pathology
  • Humans
  • Parathyroid Glands
  • Parathyroid Hormone
  • Parathyroid Neoplasms
  • Tumor Microenvironment

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