Parathyroidectomy and blood pressure in hemodialysis patients

F. Pizzarelli, F. Fabrizi, M. Postorino, G. Curatola, C. Zoccoli, Q. Maggiore

Research output: Contribution to journalArticle

Abstract

To assess whether parathyroidectomy (PTx) affects blood pressure (BP) in hemodialysis (HD) patients, we studied 11 uremics on HD treatment for 8.2 ± 0.9 years who underwent successful PTx. As the control group, we selected 11 HD patients not submitted to PTx, matched with the study group for sex, age, years on HD, dialysis procedure and BP values. In the controls, BP and body weight did not change during the 2 years Or observation. In the patients, BP remained stable in the year before PTx. PTx caused a progressive reduction in BP in 7 of the 11 patients. The fall was significant from the 3rd quarter onward (mean BP values before PTx: 139/82 mm Hg, 1 year after PTx: 122/75 mm Hg). The magnitude of the hypotensive effect of PTx was related to the pre-PTx systolic BP value (r = -0.70, p = 0.016). PTx also caused a significant progressive increase in body weight (1.56 ± 0.57 kg 1 year after PTx). In conclusion, PTx causes BP fall in HD patients regardless of whether their preintervention values are normal or increased. The BP reduction occurs in concomitance with a consistent increase in body weight. BP variations are clinically relevant and may be related to the post-PTx calcium efflux from the vessel wall.

Original languageEnglish
Pages (from-to)384-389
Number of pages6
JournalNephron
Volume63
Issue number4
Publication statusPublished - 1993

Keywords

  • Blood pressure
  • Calcium
  • Dialysis hypotension
  • Hypocalcemia
  • Parathyroidectomy

ASJC Scopus subject areas

  • Nephrology

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