Parenchymal preamyloid and amyloid deposits in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type

Willem Frederik Timmers, Fabrizio Tagliavini, Joost Haan, Blas Frangione

Research output: Contribution to journalArticlepeer-review

Abstract

Hereditary cerebral hermorrhage with amyloidosis-Dutch type, one of the 'cerebral β-amyloid diseases', like Alzheimer's disease, is characterized by extensive deposition of amyloid in small cerebral vessels. We investigated the presence of parenchymal β-protein deposits in two Dutch patients with hereditary cerebral hemorrhage with amyloidosis. Immunostaining with anti-SP28 revealed a full spectrum of these deposits, varying from preamyloid deposits to burned-out plaques. However, their density is less than in Alzheimer's desease, and immunostaining with Alz50 and anti-PHF did not show abnormal neurites in and around amyloid deposits in these two patients.

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalNeuroscience Letters
Volume118
Issue number2
DOIs
Publication statusPublished - Oct 16 1990

Keywords

  • Alzheimer's disease
  • Amyloid β-protein
  • Dementia
  • Hereditary cerebral hermorrhage with amyloidosis-Dutch type
  • Immunohistochemistry
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)

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