TY - JOUR
T1 - Parental occupations and childhood brain tumors
T2 - Results of an international case-control study
AU - Cordier, Sylvaine
AU - Mandereau, Laurence
AU - Preston-Martin, Susan
AU - Little, Julian
AU - Lubin, Flora
AU - Mueller, Beth
AU - Holly, Elisabeth
AU - Filippini, Graziella
AU - Peris-Bonet, Rafael
AU - McCredie, Margaret
AU - Choi, N. W.
AU - Arslan, Annie
PY - 2001
Y1 - 2001
N2 - Objective: To evaluate the role of parental occupations in the etiology of childhood brain tumors (CBT). Methods: Population-based case-control studies were conducted concurrently in seven countries under the coordination of the International Agency for Research on Cancer, gathering 1218 cases and 2223 controls. We report here the findings related to parental occupations during the 5-year period before the child's birth. Risk estimates related to a number of paternal and maternal occupations were obtained by unconditional logistic regression adjusted for age, sex, year of birth, and center, for all types of CBT combined and for the subgroups of astroglial, primitive neuroectodermal tumors (PNET), and other glial tumors. Results: An increased risk in relation with agricultural work was seen for all CBT combined and for other glial tumors. Increased risks for all tumors and PNET were seen for paternal occupation as an electrician; the same pattern held for maternal occupation when children under 5 were selected. Paternal occupation as a driver or mechanic, and maternal work in an environment related to motor-vehicles were associated with an increased risk for all CBT and astroglial tumors. More case mothers compared to control mothers were employed in the textile industry. Conclusion: Our study reinforces previous findings relative to the role of parental work in agriculture, electricity, or motor-vehicle related occupations and maternal work in the textile industry. It does not confirm previous associations with work environments including aerospace, the chemical industry, or the food industry, or with maternal occupation as a hairdresser, a nurse, or a sewing machinist, and paternal occupation as a welder.
AB - Objective: To evaluate the role of parental occupations in the etiology of childhood brain tumors (CBT). Methods: Population-based case-control studies were conducted concurrently in seven countries under the coordination of the International Agency for Research on Cancer, gathering 1218 cases and 2223 controls. We report here the findings related to parental occupations during the 5-year period before the child's birth. Risk estimates related to a number of paternal and maternal occupations were obtained by unconditional logistic regression adjusted for age, sex, year of birth, and center, for all types of CBT combined and for the subgroups of astroglial, primitive neuroectodermal tumors (PNET), and other glial tumors. Results: An increased risk in relation with agricultural work was seen for all CBT combined and for other glial tumors. Increased risks for all tumors and PNET were seen for paternal occupation as an electrician; the same pattern held for maternal occupation when children under 5 were selected. Paternal occupation as a driver or mechanic, and maternal work in an environment related to motor-vehicles were associated with an increased risk for all CBT and astroglial tumors. More case mothers compared to control mothers were employed in the textile industry. Conclusion: Our study reinforces previous findings relative to the role of parental work in agriculture, electricity, or motor-vehicle related occupations and maternal work in the textile industry. It does not confirm previous associations with work environments including aerospace, the chemical industry, or the food industry, or with maternal occupation as a hairdresser, a nurse, or a sewing machinist, and paternal occupation as a welder.
KW - Brain neoplasms
KW - Child
KW - Parental occupation
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U2 - 10.1023/A:1012277703631
DO - 10.1023/A:1012277703631
M3 - Article
C2 - 11714115
AN - SCOPUS:0034771466
VL - 12
SP - 865
EP - 874
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 9
ER -