Parental sex effect in familial amyotrophic lateral sclerosis

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Since a parental sex effect has been reported in Huntington’s disease, we looked to see whether a similar effect is apparent in adult (autosomal dominant) familial ALS. We analyzed the data for 145 patients, with an onset age range of 20 to 68 years and a known affected parent (AP), from 52 families described in the literature. There was a significant increase in the percentage of patients inheriting the gene from an affected mother as a function of the age at onset. There was also a significant correlation between AP and offspring age at onset only when the AP was the mother.

Original languageEnglish
Pages (from-to)1292-1294
Number of pages3
Issue number8
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)


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