Parenthood in survivors of Hodgkin lymphoma: An EORTC-GELA general population case-control study

Marleen A E Van Der Kaaij, Natacha Heutte, Paul Meijnders, Edwige Abeilard-Lemoisson, Michele Spina, Lotte C. Moser, Anouk Allgeier, Bart Meulemans, Brice Dubois, Arnold H M Simons, Pieternella J. Lugtenburg, Berthe M P Aleman, Evert M. Noordijk, Christophe Fermé, José Thomas, Aspasia Stamatoullas, Christophe Fruchart, Pauline Brice, Isabelle Gaillard, Jeanette K. DoorduijnCatherine Sebban, Wilma G J M Smit, Serge Bologna, Judith M. Roesink, Francisca Ong, Marc P E André, John M M Raemaekers, Michel Henry-Amar, Hanneke C. Kluin-Nelemans

Research output: Contribution to journalArticle

Abstract

Purpose: We investigated the impact of Hodgkin lymphoma (HL) on parenthood, including factors influencing parenthood probability, by comparing long-term HL survivors with matched general population controls. Patients and Methods: A Life Situation Questionnaire was sent to 3,604 survivors treated from 1964 to 2004 in successive clinical trials. Responders were matched with controls (1:3 or 4) for sex, country, education, and year of birth (10-year groups). Controls were given an artificial date of start of treatment equal to that of their matched case. The main end point was presence of biologic children after treatment, which was evaluated by using conditional logistic regression analysis. Logistic regression analysis was used to analyze factors influencing spontaneous post-treatment parenthood. Results: In all, 1,654 French and Dutch survivors were matched with 6,414 controls. Median follow-up was 14 years (range, 5 to 44 years). After treatment, the odds ratio (OR) for having children was 0.77 (95% CI, 0.68 to 0.87; P <.001) for survivors compared with controls. Of 898 survivors who were childless before treatment, 46.7% achieved post-treatment parenthood compared with 49.3% of 3,196 childless controls (OR, 0.87; P <.08). Among 756 survivors with children before treatment, 12.4% became parents after HL treatment compared with 22.2% of 3,218 controls with children before treatment (OR, 0.49; P <.001). Treatment with alkylating agents, second-line therapy, and age older than 35 years at treatment appeared to reduce the chances of spontaneous posttreatment parenthood. Conclusion: Survivors of HL had slightly but significantly fewer children after treatment than matched general population controls. The difference concerned only survivors who had children before treatment and appears to have more personal than biologic reasons. The chance of successful posttreatment parenthood was 76%.

Original languageEnglish
Pages (from-to)3854-3863
Number of pages10
JournalJournal of Clinical Oncology
Volume30
Issue number31
DOIs
Publication statusPublished - Nov 1 2012

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Population Control
Hodgkin Disease
Survivors
Case-Control Studies
Therapeutics
Odds Ratio
Logistic Models
Regression Analysis
Sex Education
Alkylating Agents
Statistical Factor Analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Van Der Kaaij, M. A. E., Heutte, N., Meijnders, P., Abeilard-Lemoisson, E., Spina, M., Moser, L. C., ... Kluin-Nelemans, H. C. (2012). Parenthood in survivors of Hodgkin lymphoma: An EORTC-GELA general population case-control study. Journal of Clinical Oncology, 30(31), 3854-3863. https://doi.org/10.1200/JCO.2011.40.8906

Parenthood in survivors of Hodgkin lymphoma : An EORTC-GELA general population case-control study. / Van Der Kaaij, Marleen A E; Heutte, Natacha; Meijnders, Paul; Abeilard-Lemoisson, Edwige; Spina, Michele; Moser, Lotte C.; Allgeier, Anouk; Meulemans, Bart; Dubois, Brice; Simons, Arnold H M; Lugtenburg, Pieternella J.; Aleman, Berthe M P; Noordijk, Evert M.; Fermé, Christophe; Thomas, José; Stamatoullas, Aspasia; Fruchart, Christophe; Brice, Pauline; Gaillard, Isabelle; Doorduijn, Jeanette K.; Sebban, Catherine; Smit, Wilma G J M; Bologna, Serge; Roesink, Judith M.; Ong, Francisca; André, Marc P E; Raemaekers, John M M; Henry-Amar, Michel; Kluin-Nelemans, Hanneke C.

In: Journal of Clinical Oncology, Vol. 30, No. 31, 01.11.2012, p. 3854-3863.

Research output: Contribution to journalArticle

Van Der Kaaij, MAE, Heutte, N, Meijnders, P, Abeilard-Lemoisson, E, Spina, M, Moser, LC, Allgeier, A, Meulemans, B, Dubois, B, Simons, AHM, Lugtenburg, PJ, Aleman, BMP, Noordijk, EM, Fermé, C, Thomas, J, Stamatoullas, A, Fruchart, C, Brice, P, Gaillard, I, Doorduijn, JK, Sebban, C, Smit, WGJM, Bologna, S, Roesink, JM, Ong, F, André, MPE, Raemaekers, JMM, Henry-Amar, M & Kluin-Nelemans, HC 2012, 'Parenthood in survivors of Hodgkin lymphoma: An EORTC-GELA general population case-control study', Journal of Clinical Oncology, vol. 30, no. 31, pp. 3854-3863. https://doi.org/10.1200/JCO.2011.40.8906
Van Der Kaaij, Marleen A E ; Heutte, Natacha ; Meijnders, Paul ; Abeilard-Lemoisson, Edwige ; Spina, Michele ; Moser, Lotte C. ; Allgeier, Anouk ; Meulemans, Bart ; Dubois, Brice ; Simons, Arnold H M ; Lugtenburg, Pieternella J. ; Aleman, Berthe M P ; Noordijk, Evert M. ; Fermé, Christophe ; Thomas, José ; Stamatoullas, Aspasia ; Fruchart, Christophe ; Brice, Pauline ; Gaillard, Isabelle ; Doorduijn, Jeanette K. ; Sebban, Catherine ; Smit, Wilma G J M ; Bologna, Serge ; Roesink, Judith M. ; Ong, Francisca ; André, Marc P E ; Raemaekers, John M M ; Henry-Amar, Michel ; Kluin-Nelemans, Hanneke C. / Parenthood in survivors of Hodgkin lymphoma : An EORTC-GELA general population case-control study. In: Journal of Clinical Oncology. 2012 ; Vol. 30, No. 31. pp. 3854-3863.
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abstract = "Purpose: We investigated the impact of Hodgkin lymphoma (HL) on parenthood, including factors influencing parenthood probability, by comparing long-term HL survivors with matched general population controls. Patients and Methods: A Life Situation Questionnaire was sent to 3,604 survivors treated from 1964 to 2004 in successive clinical trials. Responders were matched with controls (1:3 or 4) for sex, country, education, and year of birth (10-year groups). Controls were given an artificial date of start of treatment equal to that of their matched case. The main end point was presence of biologic children after treatment, which was evaluated by using conditional logistic regression analysis. Logistic regression analysis was used to analyze factors influencing spontaneous post-treatment parenthood. Results: In all, 1,654 French and Dutch survivors were matched with 6,414 controls. Median follow-up was 14 years (range, 5 to 44 years). After treatment, the odds ratio (OR) for having children was 0.77 (95{\%} CI, 0.68 to 0.87; P <.001) for survivors compared with controls. Of 898 survivors who were childless before treatment, 46.7{\%} achieved post-treatment parenthood compared with 49.3{\%} of 3,196 childless controls (OR, 0.87; P <.08). Among 756 survivors with children before treatment, 12.4{\%} became parents after HL treatment compared with 22.2{\%} of 3,218 controls with children before treatment (OR, 0.49; P <.001). Treatment with alkylating agents, second-line therapy, and age older than 35 years at treatment appeared to reduce the chances of spontaneous posttreatment parenthood. Conclusion: Survivors of HL had slightly but significantly fewer children after treatment than matched general population controls. The difference concerned only survivors who had children before treatment and appears to have more personal than biologic reasons. The chance of successful posttreatment parenthood was 76{\%}.",
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T1 - Parenthood in survivors of Hodgkin lymphoma

T2 - An EORTC-GELA general population case-control study

AU - Van Der Kaaij, Marleen A E

AU - Heutte, Natacha

AU - Meijnders, Paul

AU - Abeilard-Lemoisson, Edwige

AU - Spina, Michele

AU - Moser, Lotte C.

AU - Allgeier, Anouk

AU - Meulemans, Bart

AU - Dubois, Brice

AU - Simons, Arnold H M

AU - Lugtenburg, Pieternella J.

AU - Aleman, Berthe M P

AU - Noordijk, Evert M.

AU - Fermé, Christophe

AU - Thomas, José

AU - Stamatoullas, Aspasia

AU - Fruchart, Christophe

AU - Brice, Pauline

AU - Gaillard, Isabelle

AU - Doorduijn, Jeanette K.

AU - Sebban, Catherine

AU - Smit, Wilma G J M

AU - Bologna, Serge

AU - Roesink, Judith M.

AU - Ong, Francisca

AU - André, Marc P E

AU - Raemaekers, John M M

AU - Henry-Amar, Michel

AU - Kluin-Nelemans, Hanneke C.

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Purpose: We investigated the impact of Hodgkin lymphoma (HL) on parenthood, including factors influencing parenthood probability, by comparing long-term HL survivors with matched general population controls. Patients and Methods: A Life Situation Questionnaire was sent to 3,604 survivors treated from 1964 to 2004 in successive clinical trials. Responders were matched with controls (1:3 or 4) for sex, country, education, and year of birth (10-year groups). Controls were given an artificial date of start of treatment equal to that of their matched case. The main end point was presence of biologic children after treatment, which was evaluated by using conditional logistic regression analysis. Logistic regression analysis was used to analyze factors influencing spontaneous post-treatment parenthood. Results: In all, 1,654 French and Dutch survivors were matched with 6,414 controls. Median follow-up was 14 years (range, 5 to 44 years). After treatment, the odds ratio (OR) for having children was 0.77 (95% CI, 0.68 to 0.87; P <.001) for survivors compared with controls. Of 898 survivors who were childless before treatment, 46.7% achieved post-treatment parenthood compared with 49.3% of 3,196 childless controls (OR, 0.87; P <.08). Among 756 survivors with children before treatment, 12.4% became parents after HL treatment compared with 22.2% of 3,218 controls with children before treatment (OR, 0.49; P <.001). Treatment with alkylating agents, second-line therapy, and age older than 35 years at treatment appeared to reduce the chances of spontaneous posttreatment parenthood. Conclusion: Survivors of HL had slightly but significantly fewer children after treatment than matched general population controls. The difference concerned only survivors who had children before treatment and appears to have more personal than biologic reasons. The chance of successful posttreatment parenthood was 76%.

AB - Purpose: We investigated the impact of Hodgkin lymphoma (HL) on parenthood, including factors influencing parenthood probability, by comparing long-term HL survivors with matched general population controls. Patients and Methods: A Life Situation Questionnaire was sent to 3,604 survivors treated from 1964 to 2004 in successive clinical trials. Responders were matched with controls (1:3 or 4) for sex, country, education, and year of birth (10-year groups). Controls were given an artificial date of start of treatment equal to that of their matched case. The main end point was presence of biologic children after treatment, which was evaluated by using conditional logistic regression analysis. Logistic regression analysis was used to analyze factors influencing spontaneous post-treatment parenthood. Results: In all, 1,654 French and Dutch survivors were matched with 6,414 controls. Median follow-up was 14 years (range, 5 to 44 years). After treatment, the odds ratio (OR) for having children was 0.77 (95% CI, 0.68 to 0.87; P <.001) for survivors compared with controls. Of 898 survivors who were childless before treatment, 46.7% achieved post-treatment parenthood compared with 49.3% of 3,196 childless controls (OR, 0.87; P <.08). Among 756 survivors with children before treatment, 12.4% became parents after HL treatment compared with 22.2% of 3,218 controls with children before treatment (OR, 0.49; P <.001). Treatment with alkylating agents, second-line therapy, and age older than 35 years at treatment appeared to reduce the chances of spontaneous posttreatment parenthood. Conclusion: Survivors of HL had slightly but significantly fewer children after treatment than matched general population controls. The difference concerned only survivors who had children before treatment and appears to have more personal than biologic reasons. The chance of successful posttreatment parenthood was 76%.

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