Parents as source of pertussis transmission in hospitalized young infants

Giorgio Fedele, Maria Carollo, Raffaella Palazzo, Paola Stefanelli, Elisabetta Pandolfi, Francesco Gesualdo, Alberto Eugenio Tozzi, Rita Carsetti, Alberto Villani, Ambra Nicolai, Fabio Midulla, Clara Maria Ausiello, Pasqualina Leone, Ilaria Schiavoni, Gabriele Buttinelli, Michaela Veronika Gonfiantini, Eleonora Agricola, Luisa Russo, Beatrice Ferretti, Ilaria CampagnaValentina Marcellini, Carlo Concato, Antonella Frassanito, Raffaella Nenna, Greta Di Mattia, Caterina Rizzo, The Pertussis Study Group

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: This study was planned to collect evidences of familial pertussis transmission to infants younger than 6 months of age. Understanding the dynamics of transmission of pertussis in families is essential to plan effective prevention strategies that could be integrated in pertussis control. Methods: The seroprevalence of IgG antibodies to pertussis toxin (PT-IgG) and prolonged cough symptoms were evaluated in parents of 55 infants aged <6 months hospitalized for confirmed pertussis. Parents of 33 infants with lower respiratory tract infection (LRTI) and parents of 57 healthy infants admitted as outpatients for hip ultrasound examination (HE) were enrolled as controls. Results: Parents of pertussis cases had PT-IgG levels significantly higher as compared to LRTI and HE parents. More than 40 % were compatible as transmitters of pertussis to their babies, since they had a level of PT-IgG ≥ 100 IU/ml, which is considered diagnostic for a recent pertussis episode. Based on serology, the percentage of pertussis cases that had at least one parent as source of infection was 49.1 %. When cough symptoms were taken into account, the percentage of parents putative transmitters of the infection to their infants increased to 56.4 %. Conclusions: Parents are scarcely aware of the household transmission of pertussis to their newborns. Our study highlights the need to advise parents about the likelihood of transmission to the newborn and to be particularly aware of coughing symptoms in the household. Since infection can be asymptomatic, a serological survey of family members should also be considered.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalInfection
DOIs
Publication statusAccepted/In press - Sep 10 2016

Keywords

  • Infant
  • Pertussis
  • Serology
  • Source of infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Parents as source of pertussis transmission in hospitalized young infants'. Together they form a unique fingerprint.

Cite this