Parents as source of pertussis transmission in hospitalized young infants

Pertussis Study Group

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

PURPOSE: This study was planned to collect evidences of familial pertussis transmission to infants younger than 6 months of age. Understanding the dynamics of transmission of pertussis in families is essential to plan effective prevention strategies that could be integrated in pertussis control.

METHODS: The seroprevalence of IgG antibodies to pertussis toxin (PT-IgG) and prolonged cough symptoms were evaluated in parents of 55 infants aged <6 months hospitalized for confirmed pertussis. Parents of 33 infants with lower respiratory tract infection (LRTI) and parents of 57 healthy infants admitted as outpatients for hip ultrasound examination (HE) were enrolled as controls.

RESULTS: Parents of pertussis cases had PT-IgG levels significantly higher as compared to LRTI and HE parents. More than 40 % were compatible as transmitters of pertussis to their babies, since they had a level of PT-IgG ≥ 100 IU/ml, which is considered diagnostic for a recent pertussis episode. Based on serology, the percentage of pertussis cases that had at least one parent as source of infection was 49.1 %. When cough symptoms were taken into account, the percentage of parents putative transmitters of the infection to their infants increased to 56.4 %.

CONCLUSIONS: Parents are scarcely aware of the household transmission of pertussis to their newborns. Our study highlights the need to advise parents about the likelihood of transmission to the newborn and to be particularly aware of coughing symptoms in the household. Since infection can be asymptomatic, a serological survey of family members should also be considered.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalInfection
Volume45
Issue number2
DOIs
Publication statusPublished - Apr 2017

Fingerprint

Whooping Cough
Parents
Immunoglobulin G
Cough
Respiratory Tract Infections
Hip
Infection
Newborn Infant
Pertussis Toxin
Seroepidemiologic Studies
Serology
Outpatients
Antibodies

Keywords

  • Antibodies, Bacterial/blood
  • Antitoxins/blood
  • Case-Control Studies
  • Family Health
  • Female
  • Humans
  • Immunoglobulin G/blood
  • Infant
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical
  • Male
  • Parents
  • Seroepidemiologic Studies
  • Whooping Cough/transmission

Cite this

Parents as source of pertussis transmission in hospitalized young infants. / Pertussis Study Group.

In: Infection, Vol. 45, No. 2, 04.2017, p. 171-178.

Research output: Contribution to journalArticle

Pertussis Study Group. / Parents as source of pertussis transmission in hospitalized young infants. In: Infection. 2017 ; Vol. 45, No. 2. pp. 171-178.
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title = "Parents as source of pertussis transmission in hospitalized young infants",
abstract = "PURPOSE: This study was planned to collect evidences of familial pertussis transmission to infants younger than 6 months of age. Understanding the dynamics of transmission of pertussis in families is essential to plan effective prevention strategies that could be integrated in pertussis control.METHODS: The seroprevalence of IgG antibodies to pertussis toxin (PT-IgG) and prolonged cough symptoms were evaluated in parents of 55 infants aged <6 months hospitalized for confirmed pertussis. Parents of 33 infants with lower respiratory tract infection (LRTI) and parents of 57 healthy infants admitted as outpatients for hip ultrasound examination (HE) were enrolled as controls.RESULTS: Parents of pertussis cases had PT-IgG levels significantly higher as compared to LRTI and HE parents. More than 40 {\%} were compatible as transmitters of pertussis to their babies, since they had a level of PT-IgG ≥ 100 IU/ml, which is considered diagnostic for a recent pertussis episode. Based on serology, the percentage of pertussis cases that had at least one parent as source of infection was 49.1 {\%}. When cough symptoms were taken into account, the percentage of parents putative transmitters of the infection to their infants increased to 56.4 {\%}.CONCLUSIONS: Parents are scarcely aware of the household transmission of pertussis to their newborns. Our study highlights the need to advise parents about the likelihood of transmission to the newborn and to be particularly aware of coughing symptoms in the household. Since infection can be asymptomatic, a serological survey of family members should also be considered.",
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author = "{Pertussis Study Group} and Giorgio Fedele and Maria Carollo and Raffaella Palazzo and Paola Stefanelli and Elisabetta Pandolfi and Francesco Gesualdo and Tozzi, {Alberto Eugenio} and Rita Carsetti and Alberto Villani and Ambra Nicolai and Fabio Midulla and Ausiello, {Clara Maria}",
year = "2017",
month = "4",
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TY - JOUR

T1 - Parents as source of pertussis transmission in hospitalized young infants

AU - Pertussis Study Group

AU - Fedele, Giorgio

AU - Carollo, Maria

AU - Palazzo, Raffaella

AU - Stefanelli, Paola

AU - Pandolfi, Elisabetta

AU - Gesualdo, Francesco

AU - Tozzi, Alberto Eugenio

AU - Carsetti, Rita

AU - Villani, Alberto

AU - Nicolai, Ambra

AU - Midulla, Fabio

AU - Ausiello, Clara Maria

PY - 2017/4

Y1 - 2017/4

N2 - PURPOSE: This study was planned to collect evidences of familial pertussis transmission to infants younger than 6 months of age. Understanding the dynamics of transmission of pertussis in families is essential to plan effective prevention strategies that could be integrated in pertussis control.METHODS: The seroprevalence of IgG antibodies to pertussis toxin (PT-IgG) and prolonged cough symptoms were evaluated in parents of 55 infants aged <6 months hospitalized for confirmed pertussis. Parents of 33 infants with lower respiratory tract infection (LRTI) and parents of 57 healthy infants admitted as outpatients for hip ultrasound examination (HE) were enrolled as controls.RESULTS: Parents of pertussis cases had PT-IgG levels significantly higher as compared to LRTI and HE parents. More than 40 % were compatible as transmitters of pertussis to their babies, since they had a level of PT-IgG ≥ 100 IU/ml, which is considered diagnostic for a recent pertussis episode. Based on serology, the percentage of pertussis cases that had at least one parent as source of infection was 49.1 %. When cough symptoms were taken into account, the percentage of parents putative transmitters of the infection to their infants increased to 56.4 %.CONCLUSIONS: Parents are scarcely aware of the household transmission of pertussis to their newborns. Our study highlights the need to advise parents about the likelihood of transmission to the newborn and to be particularly aware of coughing symptoms in the household. Since infection can be asymptomatic, a serological survey of family members should also be considered.

AB - PURPOSE: This study was planned to collect evidences of familial pertussis transmission to infants younger than 6 months of age. Understanding the dynamics of transmission of pertussis in families is essential to plan effective prevention strategies that could be integrated in pertussis control.METHODS: The seroprevalence of IgG antibodies to pertussis toxin (PT-IgG) and prolonged cough symptoms were evaluated in parents of 55 infants aged <6 months hospitalized for confirmed pertussis. Parents of 33 infants with lower respiratory tract infection (LRTI) and parents of 57 healthy infants admitted as outpatients for hip ultrasound examination (HE) were enrolled as controls.RESULTS: Parents of pertussis cases had PT-IgG levels significantly higher as compared to LRTI and HE parents. More than 40 % were compatible as transmitters of pertussis to their babies, since they had a level of PT-IgG ≥ 100 IU/ml, which is considered diagnostic for a recent pertussis episode. Based on serology, the percentage of pertussis cases that had at least one parent as source of infection was 49.1 %. When cough symptoms were taken into account, the percentage of parents putative transmitters of the infection to their infants increased to 56.4 %.CONCLUSIONS: Parents are scarcely aware of the household transmission of pertussis to their newborns. Our study highlights the need to advise parents about the likelihood of transmission to the newborn and to be particularly aware of coughing symptoms in the household. Since infection can be asymptomatic, a serological survey of family members should also be considered.

KW - Antibodies, Bacterial/blood

KW - Antitoxins/blood

KW - Case-Control Studies

KW - Family Health

KW - Female

KW - Humans

KW - Immunoglobulin G/blood

KW - Infant

KW - Infant, Newborn

KW - Infectious Disease Transmission, Vertical

KW - Male

KW - Parents

KW - Seroepidemiologic Studies

KW - Whooping Cough/transmission

U2 - 10.1007/s15010-016-0943-6

DO - 10.1007/s15010-016-0943-6

M3 - Article

VL - 45

SP - 171

EP - 178

JO - Infection

JF - Infection

SN - 0300-8126

IS - 2

ER -