Parietal and intravascular innate mechanisms of vascular inflammation

Giuseppe A. Ramirez, Patrizia Rovere-Querini, Grazia G. Sabbadini, Angelo A. Manfredi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Sustained inflammation of the vessel walls occurs in a large number of systemic diseases (ranging from atherosclerosis to systemic vasculitides, thrombotic microangiopathies and connective tissue diseases), which are ultimately characterized by ischemia and end-organ failure. Cellular and humoral innate immunity contribute to a common pathogenic background and comprise several potential targets for therapeutic intervention. Here we discuss some recent advances in the effector and regulatory action of neutrophils and in the outcome of their interaction with circulating platelets. In parallel, we discuss novel insights into the role of humoral innate immunity in vascular inflammation. All these topics are discussed in light of potential clinical and therapeutic implications in the near future.

Original languageEnglish
Article number16
JournalArthritis Research and Therapy
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 28 2015

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Humoral Immunity
Innate Immunity
Blood Vessels
Thrombotic Microangiopathies
Inflammation
Systemic Vasculitis
Connective Tissue Diseases
Atherosclerosis
Neutrophils
Blood Platelets
Ischemia
Therapeutics

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Parietal and intravascular innate mechanisms of vascular inflammation. / Ramirez, Giuseppe A.; Rovere-Querini, Patrizia; Sabbadini, Grazia G.; Manfredi, Angelo A.

In: Arthritis Research and Therapy, Vol. 17, No. 1, 16, 28.01.2015.

Research output: Contribution to journalArticle

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