Parietal and intravascular innate mechanisms of vascular inflammation

Giuseppe A. Ramirez, Patrizia Rovere-Querini, Grazia G. Sabbadini, Angelo A. Manfredi

Research output: Contribution to journalArticlepeer-review

Abstract

Sustained inflammation of the vessel walls occurs in a large number of systemic diseases (ranging from atherosclerosis to systemic vasculitides, thrombotic microangiopathies and connective tissue diseases), which are ultimately characterized by ischemia and end-organ failure. Cellular and humoral innate immunity contribute to a common pathogenic background and comprise several potential targets for therapeutic intervention. Here we discuss some recent advances in the effector and regulatory action of neutrophils and in the outcome of their interaction with circulating platelets. In parallel, we discuss novel insights into the role of humoral innate immunity in vascular inflammation. All these topics are discussed in light of potential clinical and therapeutic implications in the near future.

Original languageEnglish
Article number16
JournalArthritis Research and Therapy
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 28 2015

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

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