Abstract
Sustained inflammation of the vessel walls occurs in a large number of systemic diseases (ranging from atherosclerosis to systemic vasculitides, thrombotic microangiopathies and connective tissue diseases), which are ultimately characterized by ischemia and end-organ failure. Cellular and humoral innate immunity contribute to a common pathogenic background and comprise several potential targets for therapeutic intervention. Here we discuss some recent advances in the effector and regulatory action of neutrophils and in the outcome of their interaction with circulating platelets. In parallel, we discuss novel insights into the role of humoral innate immunity in vascular inflammation. All these topics are discussed in light of potential clinical and therapeutic implications in the near future.
| Original language | English |
|---|---|
| Article number | 16 |
| Journal | Arthritis Research and Therapy |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 28 2015 |
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ASJC Scopus subject areas
- Rheumatology
- Immunology
- Immunology and Allergy
Cite this
Parietal and intravascular innate mechanisms of vascular inflammation. / Ramirez, Giuseppe A.; Rovere-Querini, Patrizia; Sabbadini, Grazia G.; Manfredi, Angelo A.
In: Arthritis Research and Therapy, Vol. 17, No. 1, 16, 28.01.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Parietal and intravascular innate mechanisms of vascular inflammation
AU - Ramirez, Giuseppe A.
AU - Rovere-Querini, Patrizia
AU - Sabbadini, Grazia G.
AU - Manfredi, Angelo A.
PY - 2015/1/28
Y1 - 2015/1/28
N2 - Sustained inflammation of the vessel walls occurs in a large number of systemic diseases (ranging from atherosclerosis to systemic vasculitides, thrombotic microangiopathies and connective tissue diseases), which are ultimately characterized by ischemia and end-organ failure. Cellular and humoral innate immunity contribute to a common pathogenic background and comprise several potential targets for therapeutic intervention. Here we discuss some recent advances in the effector and regulatory action of neutrophils and in the outcome of their interaction with circulating platelets. In parallel, we discuss novel insights into the role of humoral innate immunity in vascular inflammation. All these topics are discussed in light of potential clinical and therapeutic implications in the near future.
AB - Sustained inflammation of the vessel walls occurs in a large number of systemic diseases (ranging from atherosclerosis to systemic vasculitides, thrombotic microangiopathies and connective tissue diseases), which are ultimately characterized by ischemia and end-organ failure. Cellular and humoral innate immunity contribute to a common pathogenic background and comprise several potential targets for therapeutic intervention. Here we discuss some recent advances in the effector and regulatory action of neutrophils and in the outcome of their interaction with circulating platelets. In parallel, we discuss novel insights into the role of humoral innate immunity in vascular inflammation. All these topics are discussed in light of potential clinical and therapeutic implications in the near future.
UR - http://www.scopus.com/inward/record.url?scp=84924282983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84924282983&partnerID=8YFLogxK
U2 - 10.1186/s13075-015-0528-2
DO - 10.1186/s13075-015-0528-2
M3 - Article
AN - SCOPUS:84924282983
VL - 17
JO - Arthritis Research and Therapy
JF - Arthritis Research and Therapy
SN - 1478-6354
IS - 1
M1 - 16
ER -