Abstract
Among the factors that may influence thyroid size, pregnancy and its goitrogenic effect have been widely investigated, but thyroid volume and pregnancy have never been compared retrospectively, and there are no data on the possible relationship between thyroid size and parity. The purpose of this work was to evaluate the effects of pregnancy on thyroid volume in a moderate iodine deficiency area, to assess the possibility of a relationship between thyroid size and parity status in healthy females. A group of 208 nongoitrous healthy women underwent thyroid volume estimation by ultrasound examination. All subjects were euthyroid and negative for thyroid autoantibodies. They were assigned to different groups, according to the number of completed pregnancies. Five groups were formed (0, 1, 2, 3, 4 or more term pregnancies). Mean thyroid volume increased progressively among the groups: group 0 (14.8 ± 0.7 mL); group I (16.0 ± 0.9 mL); group II (17.1 ± 0.6 mL); group III (18.2 ± 0.6 mL); group IV (20.3 ± 0.9 mL). The increment in thyroid volume was statistically significant between group 0 and groups III (P <0.01) and IV (P <0.001), and also between group I and group IV (P <0.05). No independent effect of body weight and age-on thyroid volume was seen. Our results indicate that, in an area with moderate iodine deficiency, the goitrogenic effect of pregnancy is not fully reversible. Moreover, the statistically significant increase in thyroid volume, observed in relation to parity, is the first clinical demonstration of a cumulative goitrogenic effect of successive pregnancies, providing a strong argument to increase the iodine supply during pregnancy, even in conditions with moderate iodine deficiency.
| Original language | English |
|---|---|
| Pages (from-to) | 4534-4537 |
| Number of pages | 4 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 85 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2000 |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
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Parity as a thyroid size-determining factor in areas with moderate iodine deficiency. / Rotondi, Mario; Amato, Giovanni; Biondi, Bernadette; Mazziotti, Gherardo; Del Buono, Andrea; Nicchio, Maria Rotonda; Balzano, Simona; Bellastella, Antonio; Glinoer, Daniel; Carella, Carlo.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 85, No. 12, 2000, p. 4534-4537.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Parity as a thyroid size-determining factor in areas with moderate iodine deficiency
AU - Rotondi, Mario
AU - Amato, Giovanni
AU - Biondi, Bernadette
AU - Mazziotti, Gherardo
AU - Del Buono, Andrea
AU - Nicchio, Maria Rotonda
AU - Balzano, Simona
AU - Bellastella, Antonio
AU - Glinoer, Daniel
AU - Carella, Carlo
PY - 2000
Y1 - 2000
N2 - Among the factors that may influence thyroid size, pregnancy and its goitrogenic effect have been widely investigated, but thyroid volume and pregnancy have never been compared retrospectively, and there are no data on the possible relationship between thyroid size and parity. The purpose of this work was to evaluate the effects of pregnancy on thyroid volume in a moderate iodine deficiency area, to assess the possibility of a relationship between thyroid size and parity status in healthy females. A group of 208 nongoitrous healthy women underwent thyroid volume estimation by ultrasound examination. All subjects were euthyroid and negative for thyroid autoantibodies. They were assigned to different groups, according to the number of completed pregnancies. Five groups were formed (0, 1, 2, 3, 4 or more term pregnancies). Mean thyroid volume increased progressively among the groups: group 0 (14.8 ± 0.7 mL); group I (16.0 ± 0.9 mL); group II (17.1 ± 0.6 mL); group III (18.2 ± 0.6 mL); group IV (20.3 ± 0.9 mL). The increment in thyroid volume was statistically significant between group 0 and groups III (P <0.01) and IV (P <0.001), and also between group I and group IV (P <0.05). No independent effect of body weight and age-on thyroid volume was seen. Our results indicate that, in an area with moderate iodine deficiency, the goitrogenic effect of pregnancy is not fully reversible. Moreover, the statistically significant increase in thyroid volume, observed in relation to parity, is the first clinical demonstration of a cumulative goitrogenic effect of successive pregnancies, providing a strong argument to increase the iodine supply during pregnancy, even in conditions with moderate iodine deficiency.
AB - Among the factors that may influence thyroid size, pregnancy and its goitrogenic effect have been widely investigated, but thyroid volume and pregnancy have never been compared retrospectively, and there are no data on the possible relationship between thyroid size and parity. The purpose of this work was to evaluate the effects of pregnancy on thyroid volume in a moderate iodine deficiency area, to assess the possibility of a relationship between thyroid size and parity status in healthy females. A group of 208 nongoitrous healthy women underwent thyroid volume estimation by ultrasound examination. All subjects were euthyroid and negative for thyroid autoantibodies. They were assigned to different groups, according to the number of completed pregnancies. Five groups were formed (0, 1, 2, 3, 4 or more term pregnancies). Mean thyroid volume increased progressively among the groups: group 0 (14.8 ± 0.7 mL); group I (16.0 ± 0.9 mL); group II (17.1 ± 0.6 mL); group III (18.2 ± 0.6 mL); group IV (20.3 ± 0.9 mL). The increment in thyroid volume was statistically significant between group 0 and groups III (P <0.01) and IV (P <0.001), and also between group I and group IV (P <0.05). No independent effect of body weight and age-on thyroid volume was seen. Our results indicate that, in an area with moderate iodine deficiency, the goitrogenic effect of pregnancy is not fully reversible. Moreover, the statistically significant increase in thyroid volume, observed in relation to parity, is the first clinical demonstration of a cumulative goitrogenic effect of successive pregnancies, providing a strong argument to increase the iodine supply during pregnancy, even in conditions with moderate iodine deficiency.
UR - http://www.scopus.com/inward/record.url?scp=17744390769&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17744390769&partnerID=8YFLogxK
U2 - 10.1210/jc.85.12.4534
DO - 10.1210/jc.85.12.4534
M3 - Article
C2 - 11134104
AN - SCOPUS:17744390769
VL - 85
SP - 4534
EP - 4537
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 12
ER -