Parkinson's disease and reproductive life events

E. Martignoni, R. E. Nappi, A. Citterio, D. Calandrella, E. Corengia, A. Fignon, R. Zangaglia, G. Riboldazzi, C. Pacchetti, G. Nappi

Research output: Contribution to journalArticle

Abstract

Onset, progression and duration of Parkinson's disease (PD) seem to be similar in men and women but gender differences have been suggested concerning clinical aspects, such as more severe disease in men and more dyskinesia in women. Taking into account the multiple influences of sex hormones, estrogens in particular, on basal ganglia function, the present work compared the characteristics of reproductive events in PD subjects and in healthy women, with regard to onset and clinical aspects of the disease with respect to the milestones of reproductive life. A total of 150 PD women and 200 healthy women matched for age were interviewed about reproductive life and disease characteristics (if patients). As a group, the women With PD had menarche later than the controls, but in the normal range. Menopause was similar to the controls for time, type (natural) and onset (slow), but with less hormonal therapies. Women with PD had fewer children, while breast feeding and gynecological diseases were comparable to controls. The characteristics of menses were similar as far as dysmenorrhea and premenstrual syndrome (PMS). The women with PD onset before menopause had a longer disease duration, with a more frequent fluctuating stage, and longer treatment with both levodopa and dopamine agonists. They had more dysmenorrhea and PMS when compared with women with PD onset after menopause and controls.

Original languageEnglish
JournalNeurological Sciences
Volume23
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Sep 2002

Fingerprint

Parkinson Disease
Menopause
Premenstrual Syndrome
Dysmenorrhea
Menarche
Menstruation
Dopamine Agonists
Dyskinesias
Gonadal Steroid Hormones
Levodopa
Basal Ganglia
Breast Feeding
Healthy Volunteers
Estrogens
Reference Values
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Martignoni, E., Nappi, R. E., Citterio, A., Calandrella, D., Corengia, E., Fignon, A., ... Nappi, G. (2002). Parkinson's disease and reproductive life events. Neurological Sciences, 23(SUPPL. 2). https://doi.org/10.1007/s100720200082

Parkinson's disease and reproductive life events. / Martignoni, E.; Nappi, R. E.; Citterio, A.; Calandrella, D.; Corengia, E.; Fignon, A.; Zangaglia, R.; Riboldazzi, G.; Pacchetti, C.; Nappi, G.

In: Neurological Sciences, Vol. 23, No. SUPPL. 2, 09.2002.

Research output: Contribution to journalArticle

Martignoni, E, Nappi, RE, Citterio, A, Calandrella, D, Corengia, E, Fignon, A, Zangaglia, R, Riboldazzi, G, Pacchetti, C & Nappi, G 2002, 'Parkinson's disease and reproductive life events', Neurological Sciences, vol. 23, no. SUPPL. 2. https://doi.org/10.1007/s100720200082
Martignoni, E. ; Nappi, R. E. ; Citterio, A. ; Calandrella, D. ; Corengia, E. ; Fignon, A. ; Zangaglia, R. ; Riboldazzi, G. ; Pacchetti, C. ; Nappi, G. / Parkinson's disease and reproductive life events. In: Neurological Sciences. 2002 ; Vol. 23, No. SUPPL. 2.
@article{37f886c3476e4125a5789bed4f903d7d,
title = "Parkinson's disease and reproductive life events",
abstract = "Onset, progression and duration of Parkinson's disease (PD) seem to be similar in men and women but gender differences have been suggested concerning clinical aspects, such as more severe disease in men and more dyskinesia in women. Taking into account the multiple influences of sex hormones, estrogens in particular, on basal ganglia function, the present work compared the characteristics of reproductive events in PD subjects and in healthy women, with regard to onset and clinical aspects of the disease with respect to the milestones of reproductive life. A total of 150 PD women and 200 healthy women matched for age were interviewed about reproductive life and disease characteristics (if patients). As a group, the women With PD had menarche later than the controls, but in the normal range. Menopause was similar to the controls for time, type (natural) and onset (slow), but with less hormonal therapies. Women with PD had fewer children, while breast feeding and gynecological diseases were comparable to controls. The characteristics of menses were similar as far as dysmenorrhea and premenstrual syndrome (PMS). The women with PD onset before menopause had a longer disease duration, with a more frequent fluctuating stage, and longer treatment with both levodopa and dopamine agonists. They had more dysmenorrhea and PMS when compared with women with PD onset after menopause and controls.",
author = "E. Martignoni and Nappi, {R. E.} and A. Citterio and D. Calandrella and E. Corengia and A. Fignon and R. Zangaglia and G. Riboldazzi and C. Pacchetti and G. Nappi",
year = "2002",
month = "9",
doi = "10.1007/s100720200082",
language = "English",
volume = "23",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "SUPPL. 2",

}

TY - JOUR

T1 - Parkinson's disease and reproductive life events

AU - Martignoni, E.

AU - Nappi, R. E.

AU - Citterio, A.

AU - Calandrella, D.

AU - Corengia, E.

AU - Fignon, A.

AU - Zangaglia, R.

AU - Riboldazzi, G.

AU - Pacchetti, C.

AU - Nappi, G.

PY - 2002/9

Y1 - 2002/9

N2 - Onset, progression and duration of Parkinson's disease (PD) seem to be similar in men and women but gender differences have been suggested concerning clinical aspects, such as more severe disease in men and more dyskinesia in women. Taking into account the multiple influences of sex hormones, estrogens in particular, on basal ganglia function, the present work compared the characteristics of reproductive events in PD subjects and in healthy women, with regard to onset and clinical aspects of the disease with respect to the milestones of reproductive life. A total of 150 PD women and 200 healthy women matched for age were interviewed about reproductive life and disease characteristics (if patients). As a group, the women With PD had menarche later than the controls, but in the normal range. Menopause was similar to the controls for time, type (natural) and onset (slow), but with less hormonal therapies. Women with PD had fewer children, while breast feeding and gynecological diseases were comparable to controls. The characteristics of menses were similar as far as dysmenorrhea and premenstrual syndrome (PMS). The women with PD onset before menopause had a longer disease duration, with a more frequent fluctuating stage, and longer treatment with both levodopa and dopamine agonists. They had more dysmenorrhea and PMS when compared with women with PD onset after menopause and controls.

AB - Onset, progression and duration of Parkinson's disease (PD) seem to be similar in men and women but gender differences have been suggested concerning clinical aspects, such as more severe disease in men and more dyskinesia in women. Taking into account the multiple influences of sex hormones, estrogens in particular, on basal ganglia function, the present work compared the characteristics of reproductive events in PD subjects and in healthy women, with regard to onset and clinical aspects of the disease with respect to the milestones of reproductive life. A total of 150 PD women and 200 healthy women matched for age were interviewed about reproductive life and disease characteristics (if patients). As a group, the women With PD had menarche later than the controls, but in the normal range. Menopause was similar to the controls for time, type (natural) and onset (slow), but with less hormonal therapies. Women with PD had fewer children, while breast feeding and gynecological diseases were comparable to controls. The characteristics of menses were similar as far as dysmenorrhea and premenstrual syndrome (PMS). The women with PD onset before menopause had a longer disease duration, with a more frequent fluctuating stage, and longer treatment with both levodopa and dopamine agonists. They had more dysmenorrhea and PMS when compared with women with PD onset after menopause and controls.

UR - http://www.scopus.com/inward/record.url?scp=0036756962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036756962&partnerID=8YFLogxK

U2 - 10.1007/s100720200082

DO - 10.1007/s100720200082

M3 - Article

C2 - 12548356

AN - SCOPUS:0036756962

VL - 23

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - SUPPL. 2

ER -