Abstract
Onset, progression and duration of Parkinson's disease (PD) seem to be similar in men and women but gender differences have been suggested concerning clinical aspects, such as more severe disease in men and more dyskinesia in women. Taking into account the multiple influences of sex hormones, estrogens in particular, on basal ganglia function, the present work compared the characteristics of reproductive events in PD subjects and in healthy women, with regard to onset and clinical aspects of the disease with respect to the milestones of reproductive life. A total of 150 PD women and 200 healthy women matched for age were interviewed about reproductive life and disease characteristics (if patients). As a group, the women With PD had menarche later than the controls, but in the normal range. Menopause was similar to the controls for time, type (natural) and onset (slow), but with less hormonal therapies. Women with PD had fewer children, while breast feeding and gynecological diseases were comparable to controls. The characteristics of menses were similar as far as dysmenorrhea and premenstrual syndrome (PMS). The women with PD onset before menopause had a longer disease duration, with a more frequent fluctuating stage, and longer treatment with both levodopa and dopamine agonists. They had more dysmenorrhea and PMS when compared with women with PD onset after menopause and controls.
| Original language | English |
|---|---|
| Journal | Neurological Sciences |
| Volume | 23 |
| Issue number | SUPPL. 2 |
| DOIs | |
| Publication status | Published - Sep 2002 |
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ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
Cite this
Parkinson's disease and reproductive life events. / Martignoni, E.; Nappi, R. E.; Citterio, A.; Calandrella, D.; Corengia, E.; Fignon, A.; Zangaglia, R.; Riboldazzi, G.; Pacchetti, C.; Nappi, G.
In: Neurological Sciences, Vol. 23, No. SUPPL. 2, 09.2002.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Parkinson's disease and reproductive life events
AU - Martignoni, E.
AU - Nappi, R. E.
AU - Citterio, A.
AU - Calandrella, D.
AU - Corengia, E.
AU - Fignon, A.
AU - Zangaglia, R.
AU - Riboldazzi, G.
AU - Pacchetti, C.
AU - Nappi, G.
PY - 2002/9
Y1 - 2002/9
N2 - Onset, progression and duration of Parkinson's disease (PD) seem to be similar in men and women but gender differences have been suggested concerning clinical aspects, such as more severe disease in men and more dyskinesia in women. Taking into account the multiple influences of sex hormones, estrogens in particular, on basal ganglia function, the present work compared the characteristics of reproductive events in PD subjects and in healthy women, with regard to onset and clinical aspects of the disease with respect to the milestones of reproductive life. A total of 150 PD women and 200 healthy women matched for age were interviewed about reproductive life and disease characteristics (if patients). As a group, the women With PD had menarche later than the controls, but in the normal range. Menopause was similar to the controls for time, type (natural) and onset (slow), but with less hormonal therapies. Women with PD had fewer children, while breast feeding and gynecological diseases were comparable to controls. The characteristics of menses were similar as far as dysmenorrhea and premenstrual syndrome (PMS). The women with PD onset before menopause had a longer disease duration, with a more frequent fluctuating stage, and longer treatment with both levodopa and dopamine agonists. They had more dysmenorrhea and PMS when compared with women with PD onset after menopause and controls.
AB - Onset, progression and duration of Parkinson's disease (PD) seem to be similar in men and women but gender differences have been suggested concerning clinical aspects, such as more severe disease in men and more dyskinesia in women. Taking into account the multiple influences of sex hormones, estrogens in particular, on basal ganglia function, the present work compared the characteristics of reproductive events in PD subjects and in healthy women, with regard to onset and clinical aspects of the disease with respect to the milestones of reproductive life. A total of 150 PD women and 200 healthy women matched for age were interviewed about reproductive life and disease characteristics (if patients). As a group, the women With PD had menarche later than the controls, but in the normal range. Menopause was similar to the controls for time, type (natural) and onset (slow), but with less hormonal therapies. Women with PD had fewer children, while breast feeding and gynecological diseases were comparable to controls. The characteristics of menses were similar as far as dysmenorrhea and premenstrual syndrome (PMS). The women with PD onset before menopause had a longer disease duration, with a more frequent fluctuating stage, and longer treatment with both levodopa and dopamine agonists. They had more dysmenorrhea and PMS when compared with women with PD onset after menopause and controls.
UR - http://www.scopus.com/inward/record.url?scp=0036756962&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036756962&partnerID=8YFLogxK
U2 - 10.1007/s100720200082
DO - 10.1007/s100720200082
M3 - Article
C2 - 12548356
AN - SCOPUS:0036756962
VL - 23
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - SUPPL. 2
ER -