Parkinson's tremor, relief by an antiaminic drug (BC 105) - Discussion on the biochemical pathogenesis of parkinsonian tremor

Alessandro Agnoli, Massimo Casacchia, Stefano Ruggieri, Federico Volante, Neri Accornero

Research output: Contribution to journalArticlepeer-review

Abstract

Tremor is among the parkinsonian symptoms one of the most difficult to control. Even the treatment by l-DOPA does not give satisfactory results. According to recent biochemical hypothesis, a loss of functional balance of cerebral serotonin and histamine seems to be responsible for the symptom. The results obtained by the administration of antihistaminic, antiserotoninic, antiaminic and acetylcholinic drugs were quantitatively compared by using a piezoelectric accelerometer. The antihistaminic drug is found to be very active but unfavourable side effects are present, while the antiaminic drug is not less active, with the advantage of being free of such effects.

Original languageEnglish
Pages (from-to)154-158
Number of pages5
JournalZeitschrift für Neurologie
Volume202
Issue number2
DOIs
Publication statusPublished - Jun 1972

Keywords

  • Antiaminic Drugs
  • l-DOPA
  • Parkinson-Tremor
  • Tremor in Parkinson

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Medicine(all)

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