Parosteal osteoliposarcoma: A new bone tumor (from imaging toimmunophenotype)

F. Larousserie, X. Chen, Y. Ding, J. Kreshak, S. Cocchi, Xiaoyuan Huang, Xiaohui Niu, M. Alberghini, D. Vanel

Research output: Contribution to journalArticlepeer-review


Introduction: Parosteal osteosarcomas and well-differentiated liposarcomas (WDLPS) of soft tissue shareseveral features: they are slowly progressive, locally aggressive tumors, tend to recur locally, and rarelyor never metastasizes if not dedifferentiated. Their treatment is wide surgical resection.Microscopically, both are well differentiated tumors, very like their normal tissue counterpart. Theyshare simple karyotypes with supernumerary ring chromosomes or giant marker chromosomes contain-ing amplified 12q sequences including MDM2 and CDK4 genes, with subsequent overexpression of MDM2and CDK4 proteins.We present the case of a parosteal osteoliposarcoma made of closely intermingled components of alow-grade osteosarcoma and a WDLPS.Case: In a 34 year-old woman with a slowly growing mass of the arm, imaging revealed a large well-defined heterogeneous parosteal mass of the upper humerus, with two main components: bone at thebase and fat at the periphery. Microscopically, these two components were consistent respectively withlow grade osteosarcoma and WDLPS. Cells of the two components were labeled with anti-CDK4 antibody.No labeling with anti-MDM2 antibody and no signal detected with MDM2 FISH analysis were likely dueoverdecalcification. No frozen tumor tissue was available for FISH analysis nor array-CGH.Discussion: Differential diagnoses of this new entity would be a well-differentiated liposarcoma with alow-grade osteosarcomatous component that originates from the soft tissues, ruled out on imaging, andan ossifying parosteal lipoma, ruled out on immunohistochemistry.Conclusion: This is the first description of a low-grade parosteal sarcoma with two components thatmorphologically and immunophenotypically demonstrate characteristics of a parosteal osteosarcomaand of a well-differentiated liposarcoma.

Original languageEnglish
Pages (from-to)2149-2153
Number of pages5
JournalEuropean Journal of Radiology
Issue number12
Publication statusPublished - Dec 2013


  • Bone tumor
  • Parosteal liposarcoma
  • Parosteal osteoliposarcoma
  • Parosteal osteosarcoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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