Paroxetine and fluoxetine effects on mood and cognitive functions in depressed nondemented elderly patients

Giovanni Battista Cassano, Francomichele Puca, Pier Luigi Scapicchio, Marco Trabucchi, E. Aguglia, C. Albano, G. Bruzzone, L. Antico, L. Guidi, A. Tricerfi, C. Cappa, G. Smerieri, G. B. Cassano, E. Simonini, C. Tilli, F. Caserta, S. Varia, R. Cerqua, M. Califano, G. CerquaV. Chioma, D. Bertuzzi, M. Menetti, F. Corsonello, C. Zottola, L. Pranno, R. De Candia, M. Di Fiorino, A. Cerfi, A. Bani, G. Fichera, G. Bonomol, G. Giberti, S. Cassis, B. Grumelli, G. Galetti, G. Anni, A. Guala, U. Lancia, A. Saponaro, L. Longobardi, A. Bruni, C. Macchione, F. Fantò, T. Baietto, M. Martucci, J. Faronl, L. Calandriello, M. Meduri, A. E. Di Rosa, M. Cacciola, M. Mordechai, S. M. Zuccaro, E. Palummeri, A. Cella, S. Trasciatti, S. Paolucci, R. Coiro, V. Pedone, A. Angelini, F. Piani, D. Righini, E. Puca, B. Brancasi, F. Rengo, P. Abete, F. Cacciatore, C. A. Robotti, F. Bilone, M. C. Nicotra, V. Rotolo, A. Salsi, S. De Carolis, O. Scarpino, M. Del Gobbo, F. Sdanganelli, A. Di Biase, B. Pontrelli, P. G. Spilimbergo, E. Di Costanzo, M. Matranga, E. Stocchi, P. Grassini, G. Valenti, V. Fontana, M. Venuta, G. P. Guaraldi, L. Zanni, P. Verrienti, N. Stoppelli, V. Scardino, F. Vischia, E. Pirfo

Research output: Contribution to journalArticle

Abstract

Background: A large proportion of the elderly population complains of depressive symptoms. The ideal antidepressant for these patients, who often suffer from numerous concomitant diseases, should not worsen their cognitive functions and should be free of contraindications. Method: To assess the effects of 2 selective serotonin reuptake inhibitors on cognitive functions in elderly depressed patients (ICD-10 criteria), we conducted a double-blind, randomized, parallel-group, multicenter study comparing paroxetine (20-40 mg daily) and fluoxetine (20-60 mg daily) treatment for 1 year. Cognitive performance was evaluated by means of the Buschke Selective Reminding Test, the Blessed Information and Memory Test, the Clifton Assessment Schedule, the Cancellation Task Test, and the Wechsler Paired Word Test; the Hamilton Rating Scale for Depression (HAM-D) and the Clinical Anxiety Scale were administered to assess the course of depressive and anxiety symptoms, respectively. Results: 242 patients were enrolled (mean ± SD age = 75.4 ± 6.6 years). During the study, no deterioration of cognition was observed; on the contrary, most of the tested cognitive functions improved. Good antidepressant efficacy was maintained for over 1 year with both drugs, based on the percentage of responders to treatment (patients achieving a HAM-D total score <10; 60%). Both drugs showed a good tolerability and safety profile. Conclusion: The 2 antidepressants proved to be suitable for the long-term treatment of depression in the elderly and to be devoid of detrimental effects on the tested cognitive functions.

Original languageEnglish
Pages (from-to)396-402
Number of pages7
JournalJournal of Clinical Psychiatry
Volume63
Issue number5
Publication statusPublished - 2002

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Paroxetine
Fluoxetine
Cognition
Depression
Antidepressive Agents
Anxiety
Serotonin Uptake Inhibitors
International Classification of Diseases
Pharmaceutical Preparations
Multicenter Studies
Appointments and Schedules
Therapeutics
Safety
Population

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Cassano, G. B., Puca, F., Scapicchio, P. L., Trabucchi, M., Aguglia, E., Albano, C., ... Pirfo, E. (2002). Paroxetine and fluoxetine effects on mood and cognitive functions in depressed nondemented elderly patients. Journal of Clinical Psychiatry, 63(5), 396-402.

Paroxetine and fluoxetine effects on mood and cognitive functions in depressed nondemented elderly patients. / Cassano, Giovanni Battista; Puca, Francomichele; Scapicchio, Pier Luigi; Trabucchi, Marco; Aguglia, E.; Albano, C.; Bruzzone, G.; Antico, L.; Guidi, L.; Tricerfi, A.; Cappa, C.; Smerieri, G.; Cassano, G. B.; Simonini, E.; Tilli, C.; Caserta, F.; Varia, S.; Cerqua, R.; Califano, M.; Cerqua, G.; Chioma, V.; Bertuzzi, D.; Menetti, M.; Corsonello, F.; Zottola, C.; Pranno, L.; De Candia, R.; Di Fiorino, M.; Cerfi, A.; Bani, A.; Fichera, G.; Bonomol, G.; Giberti, G.; Cassis, S.; Grumelli, B.; Galetti, G.; Anni, G.; Guala, A.; Lancia, U.; Saponaro, A.; Longobardi, L.; Bruni, A.; Macchione, C.; Fantò, F.; Baietto, T.; Martucci, M.; Faronl, J.; Calandriello, L.; Meduri, M.; Di Rosa, A. E.; Cacciola, M.; Mordechai, M.; Zuccaro, S. M.; Palummeri, E.; Cella, A.; Trasciatti, S.; Paolucci, S.; Coiro, R.; Pedone, V.; Angelini, A.; Piani, F.; Righini, D.; Puca, E.; Brancasi, B.; Rengo, F.; Abete, P.; Cacciatore, F.; Robotti, C. A.; Bilone, F.; Nicotra, M. C.; Rotolo, V.; Salsi, A.; De Carolis, S.; Scarpino, O.; Del Gobbo, M.; Sdanganelli, F.; Di Biase, A.; Pontrelli, B.; Spilimbergo, P. G.; Di Costanzo, E.; Matranga, M.; Stocchi, E.; Grassini, P.; Valenti, G.; Fontana, V.; Venuta, M.; Guaraldi, G. P.; Zanni, L.; Verrienti, P.; Stoppelli, N.; Scardino, V.; Vischia, F.; Pirfo, E.

In: Journal of Clinical Psychiatry, Vol. 63, No. 5, 2002, p. 396-402.

Research output: Contribution to journalArticle

Cassano, GB, Puca, F, Scapicchio, PL, Trabucchi, M, Aguglia, E, Albano, C, Bruzzone, G, Antico, L, Guidi, L, Tricerfi, A, Cappa, C, Smerieri, G, Cassano, GB, Simonini, E, Tilli, C, Caserta, F, Varia, S, Cerqua, R, Califano, M, Cerqua, G, Chioma, V, Bertuzzi, D, Menetti, M, Corsonello, F, Zottola, C, Pranno, L, De Candia, R, Di Fiorino, M, Cerfi, A, Bani, A, Fichera, G, Bonomol, G, Giberti, G, Cassis, S, Grumelli, B, Galetti, G, Anni, G, Guala, A, Lancia, U, Saponaro, A, Longobardi, L, Bruni, A, Macchione, C, Fantò, F, Baietto, T, Martucci, M, Faronl, J, Calandriello, L, Meduri, M, Di Rosa, AE, Cacciola, M, Mordechai, M, Zuccaro, SM, Palummeri, E, Cella, A, Trasciatti, S, Paolucci, S, Coiro, R, Pedone, V, Angelini, A, Piani, F, Righini, D, Puca, E, Brancasi, B, Rengo, F, Abete, P, Cacciatore, F, Robotti, CA, Bilone, F, Nicotra, MC, Rotolo, V, Salsi, A, De Carolis, S, Scarpino, O, Del Gobbo, M, Sdanganelli, F, Di Biase, A, Pontrelli, B, Spilimbergo, PG, Di Costanzo, E, Matranga, M, Stocchi, E, Grassini, P, Valenti, G, Fontana, V, Venuta, M, Guaraldi, GP, Zanni, L, Verrienti, P, Stoppelli, N, Scardino, V, Vischia, F & Pirfo, E 2002, 'Paroxetine and fluoxetine effects on mood and cognitive functions in depressed nondemented elderly patients', Journal of Clinical Psychiatry, vol. 63, no. 5, pp. 396-402.
Cassano GB, Puca F, Scapicchio PL, Trabucchi M, Aguglia E, Albano C et al. Paroxetine and fluoxetine effects on mood and cognitive functions in depressed nondemented elderly patients. Journal of Clinical Psychiatry. 2002;63(5):396-402.
Cassano, Giovanni Battista ; Puca, Francomichele ; Scapicchio, Pier Luigi ; Trabucchi, Marco ; Aguglia, E. ; Albano, C. ; Bruzzone, G. ; Antico, L. ; Guidi, L. ; Tricerfi, A. ; Cappa, C. ; Smerieri, G. ; Cassano, G. B. ; Simonini, E. ; Tilli, C. ; Caserta, F. ; Varia, S. ; Cerqua, R. ; Califano, M. ; Cerqua, G. ; Chioma, V. ; Bertuzzi, D. ; Menetti, M. ; Corsonello, F. ; Zottola, C. ; Pranno, L. ; De Candia, R. ; Di Fiorino, M. ; Cerfi, A. ; Bani, A. ; Fichera, G. ; Bonomol, G. ; Giberti, G. ; Cassis, S. ; Grumelli, B. ; Galetti, G. ; Anni, G. ; Guala, A. ; Lancia, U. ; Saponaro, A. ; Longobardi, L. ; Bruni, A. ; Macchione, C. ; Fantò, F. ; Baietto, T. ; Martucci, M. ; Faronl, J. ; Calandriello, L. ; Meduri, M. ; Di Rosa, A. E. ; Cacciola, M. ; Mordechai, M. ; Zuccaro, S. M. ; Palummeri, E. ; Cella, A. ; Trasciatti, S. ; Paolucci, S. ; Coiro, R. ; Pedone, V. ; Angelini, A. ; Piani, F. ; Righini, D. ; Puca, E. ; Brancasi, B. ; Rengo, F. ; Abete, P. ; Cacciatore, F. ; Robotti, C. A. ; Bilone, F. ; Nicotra, M. C. ; Rotolo, V. ; Salsi, A. ; De Carolis, S. ; Scarpino, O. ; Del Gobbo, M. ; Sdanganelli, F. ; Di Biase, A. ; Pontrelli, B. ; Spilimbergo, P. G. ; Di Costanzo, E. ; Matranga, M. ; Stocchi, E. ; Grassini, P. ; Valenti, G. ; Fontana, V. ; Venuta, M. ; Guaraldi, G. P. ; Zanni, L. ; Verrienti, P. ; Stoppelli, N. ; Scardino, V. ; Vischia, F. ; Pirfo, E. / Paroxetine and fluoxetine effects on mood and cognitive functions in depressed nondemented elderly patients. In: Journal of Clinical Psychiatry. 2002 ; Vol. 63, No. 5. pp. 396-402.
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abstract = "Background: A large proportion of the elderly population complains of depressive symptoms. The ideal antidepressant for these patients, who often suffer from numerous concomitant diseases, should not worsen their cognitive functions and should be free of contraindications. Method: To assess the effects of 2 selective serotonin reuptake inhibitors on cognitive functions in elderly depressed patients (ICD-10 criteria), we conducted a double-blind, randomized, parallel-group, multicenter study comparing paroxetine (20-40 mg daily) and fluoxetine (20-60 mg daily) treatment for 1 year. Cognitive performance was evaluated by means of the Buschke Selective Reminding Test, the Blessed Information and Memory Test, the Clifton Assessment Schedule, the Cancellation Task Test, and the Wechsler Paired Word Test; the Hamilton Rating Scale for Depression (HAM-D) and the Clinical Anxiety Scale were administered to assess the course of depressive and anxiety symptoms, respectively. Results: 242 patients were enrolled (mean ± SD age = 75.4 ± 6.6 years). During the study, no deterioration of cognition was observed; on the contrary, most of the tested cognitive functions improved. Good antidepressant efficacy was maintained for over 1 year with both drugs, based on the percentage of responders to treatment (patients achieving a HAM-D total score <10; 60{\%}). Both drugs showed a good tolerability and safety profile. Conclusion: The 2 antidepressants proved to be suitable for the long-term treatment of depression in the elderly and to be devoid of detrimental effects on the tested cognitive functions.",
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TY - JOUR

T1 - Paroxetine and fluoxetine effects on mood and cognitive functions in depressed nondemented elderly patients

AU - Cassano, Giovanni Battista

AU - Puca, Francomichele

AU - Scapicchio, Pier Luigi

AU - Trabucchi, Marco

AU - Aguglia, E.

AU - Albano, C.

AU - Bruzzone, G.

AU - Antico, L.

AU - Guidi, L.

AU - Tricerfi, A.

AU - Cappa, C.

AU - Smerieri, G.

AU - Cassano, G. B.

AU - Simonini, E.

AU - Tilli, C.

AU - Caserta, F.

AU - Varia, S.

AU - Cerqua, R.

AU - Califano, M.

AU - Cerqua, G.

AU - Chioma, V.

AU - Bertuzzi, D.

AU - Menetti, M.

AU - Corsonello, F.

AU - Zottola, C.

AU - Pranno, L.

AU - De Candia, R.

AU - Di Fiorino, M.

AU - Cerfi, A.

AU - Bani, A.

AU - Fichera, G.

AU - Bonomol, G.

AU - Giberti, G.

AU - Cassis, S.

AU - Grumelli, B.

AU - Galetti, G.

AU - Anni, G.

AU - Guala, A.

AU - Lancia, U.

AU - Saponaro, A.

AU - Longobardi, L.

AU - Bruni, A.

AU - Macchione, C.

AU - Fantò, F.

AU - Baietto, T.

AU - Martucci, M.

AU - Faronl, J.

AU - Calandriello, L.

AU - Meduri, M.

AU - Di Rosa, A. E.

AU - Cacciola, M.

AU - Mordechai, M.

AU - Zuccaro, S. M.

AU - Palummeri, E.

AU - Cella, A.

AU - Trasciatti, S.

AU - Paolucci, S.

AU - Coiro, R.

AU - Pedone, V.

AU - Angelini, A.

AU - Piani, F.

AU - Righini, D.

AU - Puca, E.

AU - Brancasi, B.

AU - Rengo, F.

AU - Abete, P.

AU - Cacciatore, F.

AU - Robotti, C. A.

AU - Bilone, F.

AU - Nicotra, M. C.

AU - Rotolo, V.

AU - Salsi, A.

AU - De Carolis, S.

AU - Scarpino, O.

AU - Del Gobbo, M.

AU - Sdanganelli, F.

AU - Di Biase, A.

AU - Pontrelli, B.

AU - Spilimbergo, P. G.

AU - Di Costanzo, E.

AU - Matranga, M.

AU - Stocchi, E.

AU - Grassini, P.

AU - Valenti, G.

AU - Fontana, V.

AU - Venuta, M.

AU - Guaraldi, G. P.

AU - Zanni, L.

AU - Verrienti, P.

AU - Stoppelli, N.

AU - Scardino, V.

AU - Vischia, F.

AU - Pirfo, E.

PY - 2002

Y1 - 2002

N2 - Background: A large proportion of the elderly population complains of depressive symptoms. The ideal antidepressant for these patients, who often suffer from numerous concomitant diseases, should not worsen their cognitive functions and should be free of contraindications. Method: To assess the effects of 2 selective serotonin reuptake inhibitors on cognitive functions in elderly depressed patients (ICD-10 criteria), we conducted a double-blind, randomized, parallel-group, multicenter study comparing paroxetine (20-40 mg daily) and fluoxetine (20-60 mg daily) treatment for 1 year. Cognitive performance was evaluated by means of the Buschke Selective Reminding Test, the Blessed Information and Memory Test, the Clifton Assessment Schedule, the Cancellation Task Test, and the Wechsler Paired Word Test; the Hamilton Rating Scale for Depression (HAM-D) and the Clinical Anxiety Scale were administered to assess the course of depressive and anxiety symptoms, respectively. Results: 242 patients were enrolled (mean ± SD age = 75.4 ± 6.6 years). During the study, no deterioration of cognition was observed; on the contrary, most of the tested cognitive functions improved. Good antidepressant efficacy was maintained for over 1 year with both drugs, based on the percentage of responders to treatment (patients achieving a HAM-D total score <10; 60%). Both drugs showed a good tolerability and safety profile. Conclusion: The 2 antidepressants proved to be suitable for the long-term treatment of depression in the elderly and to be devoid of detrimental effects on the tested cognitive functions.

AB - Background: A large proportion of the elderly population complains of depressive symptoms. The ideal antidepressant for these patients, who often suffer from numerous concomitant diseases, should not worsen their cognitive functions and should be free of contraindications. Method: To assess the effects of 2 selective serotonin reuptake inhibitors on cognitive functions in elderly depressed patients (ICD-10 criteria), we conducted a double-blind, randomized, parallel-group, multicenter study comparing paroxetine (20-40 mg daily) and fluoxetine (20-60 mg daily) treatment for 1 year. Cognitive performance was evaluated by means of the Buschke Selective Reminding Test, the Blessed Information and Memory Test, the Clifton Assessment Schedule, the Cancellation Task Test, and the Wechsler Paired Word Test; the Hamilton Rating Scale for Depression (HAM-D) and the Clinical Anxiety Scale were administered to assess the course of depressive and anxiety symptoms, respectively. Results: 242 patients were enrolled (mean ± SD age = 75.4 ± 6.6 years). During the study, no deterioration of cognition was observed; on the contrary, most of the tested cognitive functions improved. Good antidepressant efficacy was maintained for over 1 year with both drugs, based on the percentage of responders to treatment (patients achieving a HAM-D total score <10; 60%). Both drugs showed a good tolerability and safety profile. Conclusion: The 2 antidepressants proved to be suitable for the long-term treatment of depression in the elderly and to be devoid of detrimental effects on the tested cognitive functions.

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