Paroxysmal dystonia and paroxysmal tremor in a young patient with multiple sclerosis

N. Nardocci, G. Zorzi, M. Savoldelli, V. Rumi, L. Angelini

Research output: Contribution to journalArticlepeer-review


A 16-year-old patient with multiple sclerosis (MS) showed paroxysmal movement disorders during a recurrence of the disease. The paroxysms took the form ot brief unilateral dystonic posturings of the right body suggestive of paroxysmal dystonia (PD); they completely receded with acetazolamide. A single episode of a high amplitude, rythmic slow and coarse generalized tremor, present at rest and increasing with movement, particularly involving the head in a no-no movement, occurred soon after recovery from PD and lasted three hours. The present report provides evidence that MS has to be considered in the diagnostic approach to symptomatic childhood PD and underlines the efficacy of acetazolamide in the treatment of PD attacks. It also describes a rare paroxysmal movement disorder, defined as paroxysmal dystonic tremor, that can be considered as falling within the spectrum of PD.

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - May 1995


  • acetazolamide
  • childhood
  • multiple sclerosis
  • paroxysmal dystonia
  • paroxysmal tremor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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