Paroxysmal episodic central thermoregulatory failure

F. Magnifico, G. Pierangeli, G. Barletta, C. Candela, P. Montagna, G. Bonavina, P. Cortelli

Research output: Contribution to journalArticlepeer-review


A 51-year-old man presenting with paroxysmal attacks of unilateral sweating for 1 year was studied. Clinical and laboratory findings made the diagnosis of Shapiro or Harlequin syndrome unlikely. The onset of the sweating "crisis" was immediately followed by a progressive decrease in rectal and skin temperature, lasting for about 2 hours. This indicated that hypothermia was related to an abnormal downward shift of the thermoregulatory set point and a delayed effect of mechanisms blocking heat dissipation.

Original languageEnglish
Pages (from-to)1300-1302
Number of pages3
Issue number8
Publication statusPublished - Apr 23 2002

ASJC Scopus subject areas

  • Neuroscience(all)


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