Partial Cystectomy Does Not Undermine Cancer Control in Appropriately Selected Patients With Urothelial Carcinoma of the Bladder: A Population-based Matched Analysist

Umberto Capitanio, Hendrik Isbarn, Shahrokh F. Shariat, Claudio Jeldres, Laurent Zini, Fred Saad, Markus Graefen, Francesco Montorsi, Paul Perrotte, Pierre I. Karakiewicz

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Cancer control outcomes after partial cystectomy (PC) are not well studied. We compared the population-based rates of overall (OS) and cause-specific survival (CSS) in patients with urothelial carcinoma of the urinary bladder (UCB) treated with PC or radical cystectomy (RC). Methods: Within the Surveillance Epidemiology and End Results-9 database, we identified 7243 patients treated with PC (n = 1573) or RC (n = 5670), who had pathologic T1-4N1-2M0 UCB. Matched Kaplan-Meier survival analyses compared the effect of PC vs RC on OS and CSS. Results: In the entire cohort, the OS and CSS estimates at 5 years were 57.2% and 76.4%, respectively, for PC patients and 50.2% and 65.8%, respectively, for RC patients (P <.001). In the cohort matched for age, race, pT stage, pN stage, tumor grade, and year of surgery, at 5 years the OS and CSS estimates were 56.0% and 73.5%, respectively, for PC patients, and 50.9% and 67.5%, respectively, for RC patients (OS, P = .03 and CSS, P <.001). When the number of removed lymph nodes was added to the matching criteria, the 5-year OS and CSS estimates were 57.2% and 70.3%, respectively, for PC patients, and 54.6% and 69.2%, respectively, for RC patients (HR 1.1, P = .3 and HR 1.1, P = .5). Conclusions: Partial cystectomy does not undermine cancer control in appropriately selected patients with UCB. Crown

Original languageEnglish
Pages (from-to)858-864
Number of pages7
JournalUrology
Volume74
Issue number4
DOIs
Publication statusPublished - Oct 2009

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Partial Cystectomy Does Not Undermine Cancer Control in Appropriately Selected Patients With Urothelial Carcinoma of the Bladder: A Population-based Matched Analysist'. Together they form a unique fingerprint.

Cite this