Partial necrosis on hepatocellular carcinoma nodules facilitates tumor recurrence after liver transplantation

Matteo Ravaioli, Gian Luca Grazi, Giorgio Ercolani, Michelangelo Fiorentino, Matteo Cescon, Rita Golfieri, Franco Trevisani, Walter Franco Grigioni, Luigi Bolondi, Antonio Daniele Pinna

Research output: Contribution to journalArticle

Abstract

Background. The presence of partial necrosis in hepatocellular carcinoma (HCC) nodules is a common histologic finding after liver transplantation, but its correlation with tumor recurrence has never been investigated. Methods. we retrospectively reviewed the outcome of 54 patients with a single histologically proven HCC after liver transplantation. All cases had a survival of more than 6 months, and patients treated preoperatively had a transarterial chemoembolization (TACE) procedure. Since 1996, our center has applied the Milan criteria. Correlations between tumor recurrences and clinicopathologic variables, including the presence of partial necrosis, were performed. Etiologic factors for HCC partial necrosis were also investigated. Results. Sixteen of 54 (29.6%) HCC nodules presented partial necrosis, and 4 (25%) of them developed HCC recurrence compared with 1 of 38 (2.6%) cases without this histologic finding (P

Original languageEnglish
Pages (from-to)1780-1786
Number of pages7
JournalTransplantation
Volume78
Issue number12
DOIs
Publication statusPublished - Dec 27 2004

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Liver Transplantation
Hepatocellular Carcinoma
Necrosis
Recurrence
Neoplasms
Survival

Keywords

  • Hepatocellular carcinoma
  • Recurrence-free survival
  • Selection criteria
  • Survival
  • Transarterial chemoembolization

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Partial necrosis on hepatocellular carcinoma nodules facilitates tumor recurrence after liver transplantation. / Ravaioli, Matteo; Grazi, Gian Luca; Ercolani, Giorgio; Fiorentino, Michelangelo; Cescon, Matteo; Golfieri, Rita; Trevisani, Franco; Grigioni, Walter Franco; Bolondi, Luigi; Pinna, Antonio Daniele.

In: Transplantation, Vol. 78, No. 12, 27.12.2004, p. 1780-1786.

Research output: Contribution to journalArticle

Ravaioli, M, Grazi, GL, Ercolani, G, Fiorentino, M, Cescon, M, Golfieri, R, Trevisani, F, Grigioni, WF, Bolondi, L & Pinna, AD 2004, 'Partial necrosis on hepatocellular carcinoma nodules facilitates tumor recurrence after liver transplantation', Transplantation, vol. 78, no. 12, pp. 1780-1786. https://doi.org/10.1097/01.TP.0000145892.97114.EE
Ravaioli, Matteo ; Grazi, Gian Luca ; Ercolani, Giorgio ; Fiorentino, Michelangelo ; Cescon, Matteo ; Golfieri, Rita ; Trevisani, Franco ; Grigioni, Walter Franco ; Bolondi, Luigi ; Pinna, Antonio Daniele. / Partial necrosis on hepatocellular carcinoma nodules facilitates tumor recurrence after liver transplantation. In: Transplantation. 2004 ; Vol. 78, No. 12. pp. 1780-1786.
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AU - Ravaioli, Matteo

AU - Grazi, Gian Luca

AU - Ercolani, Giorgio

AU - Fiorentino, Michelangelo

AU - Cescon, Matteo

AU - Golfieri, Rita

AU - Trevisani, Franco

AU - Grigioni, Walter Franco

AU - Bolondi, Luigi

AU - Pinna, Antonio Daniele

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AB - Background. The presence of partial necrosis in hepatocellular carcinoma (HCC) nodules is a common histologic finding after liver transplantation, but its correlation with tumor recurrence has never been investigated. Methods. we retrospectively reviewed the outcome of 54 patients with a single histologically proven HCC after liver transplantation. All cases had a survival of more than 6 months, and patients treated preoperatively had a transarterial chemoembolization (TACE) procedure. Since 1996, our center has applied the Milan criteria. Correlations between tumor recurrences and clinicopathologic variables, including the presence of partial necrosis, were performed. Etiologic factors for HCC partial necrosis were also investigated. Results. Sixteen of 54 (29.6%) HCC nodules presented partial necrosis, and 4 (25%) of them developed HCC recurrence compared with 1 of 38 (2.6%) cases without this histologic finding (P

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